The primary findings were that "Sustamine altered immediately post exercise the phosphorylation
state of signaling proteins in a manner that theoretically should reduce muscle protein breakdown, while whey protein accelerated the phosphorylation
of proteins in the mTOR-dependent signaling pathway thereby theoretically activating muscle protein synthesis.
To investigate the hypoglycemic mechanisms of CPEC and its two triterpenoids, glucose uptake, AMP-activated protein kinase (AMPK) activation, inhibitor of NF-[kappa]B kinase [beta] (IKK[beta]) phosphorylation
and insulin signaling transduction were detected in 3T3-L1 adipocytes using 2-NBDG uptake assay and Western blot analysis.
of proteins is central both to direct regulation of activity and to protein-protein interactions.
The cytoplasmic region of human EGFR contains an intrinsic tyrosine kinase (697-955) followed by a 231-residuelong COOH-terminal tail, which contains multiple tyrosine residues that function as phosphorylation
sites (Xia et al.
We have also determined SASH1 does not normally have tyrosine phosphorylation
in HeLa cells.
plays critical roles in the regulation of many cellular processes.
of S6 is thought to be required for the translation of a subset of mRNAs that contain a 5'-oligopyrimidine tract at their transcriptional start sites (5'-terminal oligopyrimidine, 5'-TOP) (Iwenofu et al.
The research centred on eukaryotic initiation factor 2 alpha (eIF2alpha) and two enzymes that modify it with a phosphate group; this type of modification is termed phosphorylation
Western blotting of phosphorylated signalling molecules revealed that UVB irradiation (80 mJ/cm(2)) significantly stimulated the phosphorylation
of p38, ERK and JNK, which was not suppressed by treatment with AX after irradiation.
Although, the mechanism of drug action on DAT is unclear, DAT phosphorylation
is associated with altered surface expression and DAT activity.
of Histone H3 at serine residue 10 by Msk1 during interphase marks transcriptional activation.
Summary: TEHRAN (FNA)- A laboratory study demonstrated how a new targeted drug, Elesclomol, blocks oxidative phosphorylation
, which appears to play essential role in melanoma that has not been well-understood.