phosphorylation


Also found in: Thesaurus, Medical, Encyclopedia, Wikipedia.
Related to phosphorylation: Chemiosmotic phosphorylation, Substrate level phosphorylation

phos·pho·ryl·ate

 (fŏs′fər-ə-lāt′)
tr.v. phos·pho·ryl·at·ed, phos·pho·ryl·at·ing, phos·pho·ryl·ates
To add a phosphate group to (an organic molecule).

phos′pho·ryl·a′tion n.
phos′pho·ryl·a′tive adj.

phosphorylation

(ˌfɒsfərɪˈleɪʃən)
n
(Chemistry) the chemical or enzymic introduction into a compound of a phosphoryl group (a trivalent radical of phosphorus and oxygen)
References in periodicals archive ?
The primary findings were that "Sustamine altered immediately post exercise the phosphorylation state of signaling proteins in a manner that theoretically should reduce muscle protein breakdown, while whey protein accelerated the phosphorylation of proteins in the mTOR-dependent signaling pathway thereby theoretically activating muscle protein synthesis.
To investigate the hypoglycemic mechanisms of CPEC and its two triterpenoids, glucose uptake, AMP-activated protein kinase (AMPK) activation, inhibitor of NF-[kappa]B kinase [beta] (IKK[beta]) phosphorylation and insulin signaling transduction were detected in 3T3-L1 adipocytes using 2-NBDG uptake assay and Western blot analysis.
Phosphorylation of proteins is central both to direct regulation of activity and to protein-protein interactions.
The cytoplasmic region of human EGFR contains an intrinsic tyrosine kinase (697-955) followed by a 231-residuelong COOH-terminal tail, which contains multiple tyrosine residues that function as phosphorylation sites (Xia et al.
We have also determined SASH1 does not normally have tyrosine phosphorylation in HeLa cells.
The phosphorylation of S6 is thought to be required for the translation of a subset of mRNAs that contain a 5'-oligopyrimidine tract at their transcriptional start sites (5'-terminal oligopyrimidine, 5'-TOP) (Iwenofu et al.
The research centred on eukaryotic initiation factor 2 alpha (eIF2alpha) and two enzymes that modify it with a phosphate group; this type of modification is termed phosphorylation.
Western blotting of phosphorylated signalling molecules revealed that UVB irradiation (80 mJ/cm(2)) significantly stimulated the phosphorylation of p38, ERK and JNK, which was not suppressed by treatment with AX after irradiation.
Although, the mechanism of drug action on DAT is unclear, DAT phosphorylation is associated with altered surface expression and DAT activity.
The phosphorylation of Histone H3 at serine residue 10 by Msk1 during interphase marks transcriptional activation.
Summary: TEHRAN (FNA)- A laboratory study demonstrated how a new targeted drug, Elesclomol, blocks oxidative phosphorylation, which appears to play essential role in melanoma that has not been well-understood.

Full browser ?