Most medical problems related to multiple myeloma are caused by the build-up of abnormal plasma cells
in the bone marrow and the presence of paraprotein in the blood or in the urine.
While calcium signalling typically controls a wide range of cellular processes that allow cells to adapt to changing environments, it was found to inhibit the expression of the membrane proteins essential for plasma cell
Nonsecretory myelomas are defined by a clinical and anatomical diagnosis of plasma cell
dyscrasia with un detectable monoclonal protein in the serum (1).
This EuroFlow[TM] tube proved sufficient for the specific identification, enumeration and discrimination between normal/reactive and aberrant plasma cells
, being used for the initial screening of Plasma Cell
Per these criteria, the increased IgG4 plasma cells
should also be present in the setting of previously described lymph node histology: follicular hyperplasia, interfollicular/immunoblastic expansion, progressive transformation of germinal centers, plasma cell
Castleman disease-like, and inflammatory pseudotumor-like.
Abnormal plasma cells
secrete abnormal immunoglobulins that can be detected monoclonally (M peak) in serum and/or urine via electrophoresis.
Tokyo, Apr 22, 2011 - (JCN Newswire) - An article in Science Signaling by researchers at the RIKEN Research Center for Allergy and Immunology (RCAI) has clarified for the first time the mechanism governing differentiation of B cells into antibody-producing plasma cells
The plasma cell
has been designed to be easy to operate and simple to maintain with the added benefit of being compact - a good solution for a small production facility perhaps.
The silenced gene profile was compared and contrasted to normal plasma cells
, which are highly specialised and for which growth and lifetime is tightly controlled.
Postinflammatory tumors of the lung; report of four cases simulating xanthoma, fibroma, or plasma cell
Patients with MGUS are, by definition, asymptomatic and have low levels of plasma cells
(less than 10% in bone marrow), but a proportion of these patients will evolve over time.
Histologic endometritis--defined as the presence of at least five neutrophils in the superficial endometrial epithelium per 400X field and at least one plasma cell
per 120X field of endometrial tissue--is common in women with lower genital tract infection who do not have signs or symptoms of acute pelvic inflammatory disease (PID), but there are conflicting data regarding whether treatment for the histologic diagnosis is warranted, said Dr.