plasminogen activator


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Related to plasminogen activator: streptokinase, Plasminogen activator inhibitor
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Noun1.plasminogen activator - protease produced in the kidney that converts plasminogen to plasmin and so initiates fibrinolysis
peptidase, protease, proteinase, proteolytic enzyme - any enzyme that catalyzes the splitting of proteins into smaller peptide fractions and amino acids by a process known as proteolysis
References in periodicals archive ?
Though limited by a smaller number of postimplementation cases and lack of 3-month poststroke functional outcome data, the findings suggest that 24/7 in-hospital availability of a neurologist improves door to intravenous tissue plasminogen activator treatment times and in-hospital stroke mortality, Dr.
3) Alteplase 20 mg (Recombinant Tissue Plasminogen Activator (TNK-t-PA) 20 mg )
Recombinant tissue plasminogen activator for acute ischaemic stroke an updated systematic review and meta-analysis.
Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction.
The report provides comprehensive information on the Plasminogen Activator Inhibitor-1 (Endothelial Plasminogen Activator Inhibitor or Serpin E1 or PAI-1), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
After failure of streptokinase thrombolysis with IV recombinant tissue plasminogen activator (TPA)was studied.
3] Nonstandard abbreviations: TF, tissue factor; FVIIa, activated factor VII; TM, thrombomodulin; PC, protein C; EPCR, endothelial protein C receptor; APC, activated PC; PS, protein S; AT, antithrombin; TFPI, tissue factor pathway inhibitor; tPA, tissue plasminogen activator; uPA, urokinase plasminogen activator; PAI, plasminogen activator inhibitor; PI, plasmin inhibitor; TAFI, thrombin activatable fibrinolysis inhibitor; ROTEM/TEG, thromboelastometry/thromboelastography; T2MR, T2 magnetic resonance.
The company will be enrolling around 60 patients in the trial from around 15 sites within and outside the United States with Rutherford Category IIa and IIb acute lower limb ischemia receiving catheter-directed recombinant tissue plasminogen activator and compare a high and low dose of MST-188 against recombinant tissue plasminogen activator alone.
Urokinase plasminogen activator is elevated in ALI where pulmonary arterial contractility and permeability are disrupted; and in nonpathologic concentrations, urokinase plasminogen activator reduces pulmonary arterial contractility and increases permeability via activation of N-methyl-D-aspartate receptor 1.
Recombinant tissue plasminogen activator (rtPA), which is commonly used for the treatment of myocardial infarction and stroke in adults, has also been used to treat cardiac thrombi in patients with congenital heart disease and right-to-left shunting (2), (3), (4).
Plasmin degradation of the alpha chain of fibrinogen/fibrin: improved activation constant and activity determination in assays for tissue plasminogen activator

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