VASP phosphorylation closely correlates with inhibition of fibrinogen binding to glycoprotein IIb/IIIa (GP IIb/IIIa) (18, 24), and it affects initial sequences of platelet adhesion
and activation by modulating interactions of platelet actin filaments (4,19).
Insulin resistance affects the procoagulant state by co-segregating with abnormalities involved in coagulation, including platelet aggregability, platelet adhesion
and increased levels of thromboxane, von Willebrand factor, factor VIII, tissue plasminogen activator and fibrinogen.
Qualitative platelet abnormalities DISORDERS OF PLATELET ADHESION
Congenital adhesion disorders Bernard Soulier syndrome: GP Ib/IX/V deficiency Von Willebrand disease Acquired defects of platelet adhesion
myeloproliferative disorders lymphoproliferative disorders, multiple myeloma and dysproteinemias antiplatelet antibodies cardiopulmonary bypass chronic liver disease rrug-induced membrane modification DISORDERS OF PLATELET AGGREGATION Congenital aggregation abnormalities Glanzmann thrombasthenia: [alpha]IIb/[[beta].
Von Willebrand Factor, or vWF, is the key adhesive protein that mediates platelet adhesion
and aggregation in the PFA-100 test cartridge.
Static platelet adhesion
studies using platelet rich plasma showed significantly reduced platelet adhesion
on the surface of the modified polymer compared to control PVC.
It targets critical applications in life science research and drug discovery, which include: cell adhesion, platelet adhesion
, cell migration and invasion, biofilms, and stem cell research.
These include platelet aggregation studies, platelet count before and after stimulation, adhesion to polymer beads, quantification of high shear platelet adhesion
and aggregation, urinary 11-dehydrothromboxane B2, thromboxane generation and platelets flow cytometry.
interference with platelet adhesion
to the subendothelium by blocking the collagen binding site.
Other methods include measurement of fibrinogen binding or platelet adhesion
2] for platelets, which suggests that maximum red cell and platelet adhesion
would occur on glass.
Typical life science applications include cell invasion, migration, adhesion, chemotaxis, platelet adhesion
and aggregation, wound healing, stem cell differentiation, and microbial biofilm formation.
However, as the platelet adhesion
and activation of intrinsic coagulation are minimal on drug-coated stent, it is not likely that thrombotic complications will be a problem on these stents.