and degranulation induce pro-survival and pro-angiogenic signaling in ovarian cancer cells.
Endothelial cells mediate a number of processes, including coagulation, platelet adhesion
and immune function.
This disease is caused by mutations in one of the three genes coding for the glycoprotein complex (GP)-IX-V 1b (CD42b-CD42a, CD42d), which function as a receptor for vWF, also affecting platelet adhesion
9]/l) 367,8 [+ or -] 10,4 Platelet adhesion
(%) 33,8 [+ or -] 1,7 Platelet aggregation (s) 22,0 [+ or -] 0,7 Clotting time Lee-White (min) in 5,1 [+ or -] 0,53 non-siliconized tube in siliconized tube 7,1 [+ or -] 0,7 Starting clotting (s) 483,8 [+ or -] 21,7 Duration of blood clotting (s) 253,0 [+ or -] 2,8 Closing clotting (s) 720,1 [+ or -] 21,9 Blood viscosity (unit of activity) 2,6 [+ or -] 0,5 The density of blood (units of activity) 0,02 [+ or -] 0,5 Plasma recalcification time (s) 120,0 [+ or -] 2,3 Plasma kaolin time (s) 89,3 [+ or -] 1,0 Kaolin cephalin time (s) 39,3 [+ or -] 1,2 ACT (s) for 6 min.
due to collagen occurred within 60 s, and secondary platelet accumulation/aggregation continued after 150 s of perfusion (Fig.
Von Willebrand Factor (VWF) is a polymeric plasma glycoprotein comprising multiple 250-kDa subunits that facilitates platelet adhesion
to the vessel wall by linking platelet membrane receptors to the subendothelium and is the cornerstone of platelet--endothelial interaction.
For example, in some cardiovascular devices the materials used caused platelet adhesion
on the surface and prevented the device from functioning properly.
An important rationale for this approach has been the observation that endothelium-derived nitric oxide (NO), a major mediator of endothelium-dependent vasodilation, has important anti-inflammatory and antithrombotic properties, ie, inhibiting leukocyte adhesion, limiting platelet adhesion
and aggregation, and the expression of plasminogen activator inhibitor-1 (PAI-1), a prothrombotic protein.
The platelet adhesion
onto the modified microspheres was also observed through the SEM after ethanol drying, critical point drying and gold sputtering.
The polymers can suppress protein adsorption, platelet adhesion
, and platelet activation at blood-contacting surfaces and they can also be solute permeable.
According to Teleflex, the device can reduce platelet adhesion
and thrombus accumulation through both in-vitro and animal testing.
Defects in Glanzmann thrombasthenia and LAD-III (LAD-1/v) syndrome: the role of integrin [beta]1 and [beta]3 in platelet adhesion