Lenvatinib simultaneously inhibits the activities of several different receptors including vascular endothelial growth factor receptors (VEGFR), fibroblast growth factor receptors (FGFR), RET, KIT and platelet-derived growth factor
Increased dermal expression of platelet-derived growth factor
receptors in growth-activated skin wounds and psoriasis, J Invest Dermatol 1991;96:983-986.
The degranulation of the platelets produces platelet-derived growth factor
(PDGF) and transforming growth factor beta (TGF-B).
We used the aptamer 41t, which is capable of binding with high affinity to the [beta] chain of the platelet-derived growth factor
protein (22), as a negative control; it did not inhibit VEGF-A detection (Fig.
Recombinant human platelet-derived growth factor
(rhPDGF) is now used widely in bone and periodontal regeneration and treatment of gingival recession, as is recombinant human bone morphogenic protein 2 (rhBMP-2) in sinus floor reconstruction and alveolar ridge augmentation associated with extraction sockets.
Chemotactic and vasoactive factors that stimulate growth and healing (3) Human growth hormone Epidermal growth factor Platelet-derived growth factor
Fibroblast growth factor Transforming growth factor Nerve growth factor Brain-derived neurotrophic factor Ciliary neurotrophic factor Insulin-like growth factor 1 Tumor necrosis factor Interleukins Interferons Keratinocyte growth factor
The expression of CD44, cyclooxygenase 2, and platelet-derived growth factor
receptor [alpha] (PDGFR-[alpha]) was evaluated as a potential prognostic factor for survival in patients with RCC.
In addition, other hypoxia-inducible genes, including BCL-2 binding protein Nip3, EGLN1, hypoxia-inducible gene 1 (HIG1), prolyl-4 hydroxylase, and cyclin G2, and growth factors, such as platelet-derived growth factor
BB and vascular endothelial growth factor (VEGF), are up-regulated by Ni(II) in an HIF-dependent manner (Kuwabara et al.
decreased platelet-derived growth factor
(PDGF); decreased basic fibroblast growth factor (b-FGF); increased keratan sulfate; increased stromelysin; increased ratio of stromelysin to tissue inhibitor of metalloproteases (TIMP); increased osteocalcin; increased alkaline phosphatase; increased cAMP responsive to hormone challenge; increased urokinase plasminogen activator; increased cartilage oligomeric matrix protein; and increased collagenase.
2,8) The gene rearrangements fuse the collagen type I Al (COLlAl) protein gene on chromosome 17 with the platelet-derived growth factor
[beta] chain (PDGFB) on chromosome 22; PDGFB is a potent mitogen and has been implicated in transforming processes via autocrine and paracrine pathways.
It is a topical gel that contains a genetically engineered, platelet-derived growth factor