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The abovementioned protective effects promoted by Cr are likely to depend on multiple mechanisms, a notion in line with the well-established Cr pleiotropism [3,12, 50-52].
However, the reasons for the pleiotropism and variability of SLC29A3 -related diseases are not known.
These effects have to be checked in these mutants from the beginning and their performance must be evaluated, as ever since the economical value of a desirable mutant may finally depend on favorable or unfavorable characters connected with the mutant by linkage or pleiotropism.