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Related to pleiotropy: pleiotropism, epistasis


 (plī-ŏt′rə-pē) also plei·ot·ro·pism (-pĭz′əm)
n. Biology
The production of diverse effects, especially the production by a single gene of several distinct and seemingly unrelated phenotypic effects.

[Greek pleiōn, more; see pelə- in Indo-European roots + -tropism.]

plei′o·tro′pic (plī′ə-trō′pĭk, -trŏp′ĭk) adj.


(plaɪˈɒ trə pi)

the phenomenon of one gene affecting more than one phenotypic characteristic.
plei`o•trop′ic (-əˈtrɒp ɪk, -ˈtroʊ pɪk) adj.
plei`o•trop′i•cal•ly, adv.
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References in periodicals archive ?
Moreover, synthesizing our results in the context of biological networks will provide the opportunity to decipher how epistasis and pleiotropy impacted adaptive trajectories.
This pleiotropy is what makes this family of compounds so valuable.
Pleiotropy in the melanocortin system, coloration and behavioural syndromes.
Antagonistic pleiotropy is the model that places this process in the context of evolutionary biology, whereby the selection process that dictated the energy devoted to the young human brain also defines its decline (called "senescence" or biological aging).
The field also includes evolutionary studies, intra-genomic phenomena such as heterosis, epistasis, pleiotropy and other interactions between loci and alleles within the genome (22).
The research team found that pleiotropy and assortative mating were about equally responsible for the genetic connection between height and IQ.
Statistics from phenotypic traits indicate that there were very high positive phenotypic correlations between body weight and morphological traits in reciprocal hybrids, suggesting pleiotropy in the determination of those traits.
The clinical development of curcumin, that has been shown to act on a pleiotropy of targets, has been hampered by its very low oral bioavailability and absorption.
Pleiotropy is the production of multiple, often seemingly unrelated, physical effects caused by a single altered gene or pair of altered genes.
These bacteria provide strong evidence that the evolution of antibiotic resistance is governed by two properties of genes, pleiotropy and epistasis.
This pleiotropy makes it unpredictable to say whether the combined effects of sirolimus and curcumin on cell proliferation and especially on immunosuppression may be synergistic or not.
Multiple inheritance patterns (autosomal dominant and recessive, X-linked, sporadic), variable penetrance, pleiotropy, and genetic anticipation complicate the diagnosis of DC (2).