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pleiotropism
(redirected from pleiotropy)

    Also found in: Medical, Encyclopedia, Wikipedia 0.01 sec.
plei·ot·ro·pism  (pl-tr-pzm) also plei·ot·ro·py (-p)
n.
The control by a single gene of several distinct and seemingly unrelated phenotypic effects.
[Greek plein, more; see pel-1 in Indo-European roots + -tropism.]
pleio·tropic (pl-trpk, -trpk) adj.
pleio·tropi·cal·ly adv.
pleiotropism [plaɪˈɒtrəˌpɪzəm]
n
(Life Sciences & Allied Applications / Genetics) Genetics the condition of a gene of affecting more than one characteristic of the phenotype
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It may be that our understanding of pleiotropy is too simplistic.
Old genes can learn new tricks by Asian News International
systemic, inflammatory state, and fits with the antagonistic pleiotropy theory on the evolution of aging postulating that senescence is the late deleterious effect of genes (pro-inflammatory versus anti-inflammatory) that are beneficial in early life.
Is inflammaging an auto[innate]immunity subclinical syndrome? by Life Extension
About 50 years ago, George Williams (13) published what has been called the antagonistic pleiotropy theory which hypothesizes that a gene that may have a positive impact on several traits (pleiotropy) may actually lead to detrimental effects by affecting fitness in a negative manner (antagonistic) at a later stage in life.
The link between healthcare, sexuality, and successful aging by Williams, Richard Allen / Forum on Public Policy: A Journal of the Oxford Round Table
 
 
 
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