Moreover, synthesizing our results in the context of biological networks will provide the opportunity to decipher how epistasis and pleiotropy
impacted adaptive trajectories.
is what makes this family of compounds so valuable.
in the melanocortin system, coloration and behavioural syndromes.
is the model that places this process in the context of evolutionary biology, whereby the selection process that dictated the energy devoted to the young human brain also defines its decline (called "senescence" or biological aging).
The field also includes evolutionary studies, intra-genomic phenomena such as heterosis, epistasis, pleiotropy
and other interactions between loci and alleles within the genome (22).
The research team found that pleiotropy
and assortative mating were about equally responsible for the genetic connection between height and IQ.
Statistics from phenotypic traits indicate that there were very high positive phenotypic correlations between body weight and morphological traits in reciprocal hybrids, suggesting pleiotropy
in the determination of those traits.
The clinical development of curcumin, that has been shown to act on a pleiotropy
of targets, has been hampered by its very low oral bioavailability and absorption.
is the production of multiple, often seemingly unrelated, physical effects caused by a single altered gene or pair of altered genes.
These bacteria provide strong evidence that the evolution of antibiotic resistance is governed by two properties of genes, pleiotropy
makes it unpredictable to say whether the combined effects of sirolimus and curcumin on cell proliferation and especially on immunosuppression may be synergistic or not.
Multiple inheritance patterns (autosomal dominant and recessive, X-linked, sporadic), variable penetrance, pleiotropy
, and genetic anticipation complicate the diagnosis of DC (2).