Gina suffers from a rare case of Plexiform
Neurofibromatosis Type 1 in which benign tumors grow around peripheral nerves.
Reflecting the partitioning of visual information into parallel channels, the retinal layer in which bipolar cell axon terminals meet their synaptic partners, is highly organized: This so-called inner plexiform
layer effectively serves as the retina s switch board : The input is provided by the different bipolar cell channels , while the output is carried by an even larger number of channels, represented by ganglion cells that form the optic nerve.
In June 2015, interim results from a Phase 1 trial in children and young adults with NF1 and plexiform
neurofibromas (PNs) were presented at the Children's Tumor Foundation NF conference.
Senile degenerative retinoschisis is an idiopathic splitting between the inner nuclear and outer plexiform
layers of the peripheral retina.
schwannoma has been rarely reported in association with NF2.
Histologically, the cells were loosely arranged without a prominent plexiform
The inner segment and outer segment lines, external limiting membrane and the inner retinal structure including retinal nerve fiber layer (RNFL) and plexiform
layer can be visualized more clearly by SD-OCT with 5 pm axial resolution.
Neurons with a shrunken cytoplasm and nucleus were observed in all HSZBoPrPTg037 mice, and these appeared in the molecular layer of the cerebellum, hippocampus (mainly plexiform
layers and hilus), thalamus, and pons.
Mechanisms of loss of heterozygosity in neurofibromatosis type 1-associated plexiform
A first-degree relative with any type, or one plexiform
NF II and unilateral 8th nerve neurofibroma mass or 2 of the following: Neurofibroma, meningioma, glioma, neurilemoma or juvenile posterior subcapsular cataract 3.
Alternative to surgery is not readily feasible, for instance radiation therapy is not possible in diffused cases, however, in solitary plexiform
type radiotherapy may retard growth and shrink the tumour .
58,59) Others are known to develop a vasculopathy similar to that seen in PSS, characterized by noninflammatory vascular remodeling and ultimately leading to plexiform