competence of cells associated with Nanog activity.
The collaboration with Wernet, Scholer and RheinCell Therapeutics will seek to develop a collection of induced Pluripotential
Stem Cell (iPSC) lines from which differentiated cells and tissues can be generated to provide therapies to repair and regenerate damaged tissues -- with a low chance of immune rejection -- for clinical use by large segments of the patient population.
Wnt/[beta]-catenin signaling plays significant roles in both embryonic development and tumorigenesis, and when activated induces differentiation of mesenchymal cells with pluripotential
into osteoblast progenitors to become osteoblasts.
6) Other theories suggest (1) the differentiation of displaced pluripotential
neuroectodermal cells into mature brain tissue and (2) detachment of extracranial embryonic tissue independent of cranial closure.
The implicated cells of origin for primary EMPD include apocrine glands, anogenital mammary-like glands, vulvar Toker cells, or possibly, pluripotential
This finding supports the concept that MDB-forming hepatocytes have progenitor and pluripotential
properties and eventually may transform into TISC cells.
Transplantation of pluripotential
nuclei from triploid frog tumors.
stem cell Myeloid Progenitors Myeloblast Monoblasts Marrow pool Mitotic Promelocytes Promonocytes precursors Myelocytes Post-mitotic Metamyelocytes bands Blood and Neutrophils, Monocytes tissue eosinophils and function basophils Innate Macrophage immunologic function Progenitors Megakaryocyte Erythroid Lymphoid Marrow pool Mitotic Maturing Normoblasts Pre-B precursors megakaryocytes Post-mitotic Reticulocytes B lymphoblast Blood and Platelets Erythrocytes B tissue lymphocytes function and plasma cells Haemostasis Oxygen Adaptive transport immunologic function Progenitors Marrow pool Mitotic Pro-T precursors Post-mitotic Lymphoblast Blood and T-lymphocytes tissue and NK cells function Fig.
The primary defect involves a pluripotential
stem cell capable of differentiating into RBCs, granulocytes, and platelets.
Establishment in culture of pluripotential
cells from mouse embryos.
See also Hans-Werner Denker, "Induced Pluripotential
Stem Ceils: How to Deal with the Developmental Potential," Reproductive BioMedicine Online 19 (2009) 34-37.
EGFR, IGF-1R, pluripotential
inhibitor of and CXCR4)  EGFR, HER2 and IGF-1R [19--for review] PTEN deficiency/PI3K activation Direct inhibition of mutations [37,51] PI3K-signalling pathway [36,40]