pestis was initially passed from person to person--say, when an infected individual coughed on a healthy person--and most likely caused lung infections known as pneumonic plague
or blood infections called septicemic plague, the researchers report in the Oct.
The authors-Amesh Adalja, Eric Toner, and Tom Inglesby-review the clinical management of conditions resulting from exposure to the category A agents that merit the most concern as potential bioterror agents: anthrax, smallpox, pneumonic plague
, botulism, and tularemia.
is one of the most deadly infectious diseases and can kill people within 24 hours.
If the pathogen is transmitted as an aerosol by droplets or by contaminated dust, primary pneumonic plague
Each new patient with clinically suspected pneumonic plague
was admitted to an isolation center to receive the first doses of the national protocol treatment.
Besides being spread through dispersion of aerosol, as would be expected in bioterrorism, pneumonic plague
can be spread from an infected rodent to a person by means of infected fleas and person to person through large droplet aerosol.
Transmissions of the infection to humans through flea bites can cause bubonic plague, which can progress to blood infection or pneumonic plague
if not treated.
Recent outbreaks or bubonic and pneumonic plague
in India posed little threat to public health in the United States, according to CDC officials.
Company scientists also hope to discover new compounds for biodefense-related diseases such as pneumonic plague
Ten days of oral doxycycline (4 mg/kg/d) combined with oral rifampin (20 mg/kg/d) and intramuscular gentamicin (3 mg/kg/d) cured the patients with bubonic plague, but the patient with pneumonic plague
II-4 Biological Agents/Diseases with Potential for Biological Warfare II-4 Properties of Biological Agents with Potential for Use as Weapons of Mass Destruction II-5 Anthrax II-6 The Anthrax History II-6 Types of Anthrax II-7 Inhalational Anthrax II-7 Cutaneous Anthrax II-7 Gastrointestinal Anthrax II-7 The Anthrax Symptoms, Treatment, and Vaccination II-7 Smallpox II-8 The Smallpox History II-8 Plague II-9 The Plague History II-9 Types of Plague II-9 Bubonic Plague II-9 Pneumonic Plague
II-10 Botulism II-10 Tularemia II-11 The Tularemia History II-12 Viral Hemorrhagic Fevers II-12 Ebola Hemorrhagic Fever II-12 Marburg Hemorrhagic Fever II-13 Lassa Hemorrhagic Fever II-13 Q Fever II-14 Brucellosis II-15 Ricin II-16 Others II-16 3.
This differs from injectable vaccines which typically take longer to confer immunity, and do not stimulate mucosal immunity - the first line of defense against pathogens like pneumonic plague
that are inhaled.