FOP is caused by a point mutation
in the ALK2/BMP Type I receptor; the mutation results in over-activity of the receptor.
Most of the middle section of the book is devoted to discussions of the genomes and proteomes of the fungi with coverage of genome structure, genomic and proteomic techniques used to study fungal/host interactions, and the repeat-induced point mutation
system (RIP) which was the first system of genomic stabilization discovered in eukaryotes in the 1980s.
It has developed its flagship technology, PointMan, which provides a reliable and highly sensitive determination of the presence or absence of a point mutation
, which is a random mutation that occurs at one point in the DNA sequence.
We have recently cloned and characterized a cytochrome b gene fragment that bears a point mutation
which confers resistance to the quinone-outside inhibiting (QoI) fungicides in A.
The nonidentical specimen came from Spain and had a previously unpublished single C--T point mutation
in variable segment 2 at position 517 when compared with L2b/UCH-1/proctitis.
During this time, patients with a specific point mutation
in the gene that helps break down the drug, UGT, metabolize the drug slower.
No point mutation
was observed and all four isolates presented wild-type sequences at DHPS gene by RFLP analysis.
When compared with the gene coding for isoxaben or TZ-sensitive cellulose synthase, one of the resistant CS genes contains a point mutation
, wherein glycine residue 998 is replaced by an aspartic acid.
5) The cause is believed to involve a point mutation
on chromosome 20 (20q12-q13) within the Gs alpha region; as a result of the mutation, the activity of the Gs protein, and thus of adenyl cyclase, is increased.
The most likely explanation is the low genetic barrier to resistance produced by synergistic selection pressure from all 3 drugs for 2 point mutation
, M184V and K65R.
A novel point mutation
in the 3' region of the prothrombin gene at position 20221 in a Lebanese/Syrian family.
Initial studies into developing a series of fluorescent SNP detection probes have been performed using the point mutation
of the human [beta]-globin gene known to cause sickle cell anemia as a model.