PTG-300 is currently in clinical development for the potential treatment of beta-thalassemia, and may also be potentially beneficial in other diseases such as myelodysplastic syndrome, hereditary hemochromatosis, polycythemia
vera, siderophilic infections, and liver fibrosis.
Researchers at the National Institutes of Health have cured mice with Chuvash polycythemia
, a life-threatening disorder that involves the overproduction of red blood cells.
Kridin and his colleagues measured the prevalence of acute and chronic leukemia, Hodgkin and non-Hodgkin lymphoma, multiple myeloma, and polycythemia
Impact is developing fedratinib for myelofibrosis and polycythemia
The presence of polycythemia
may have been responsible for the hypocalcemia as proposed in another case report.
Osumi et al reported secondary polycythemia
due to increased EPO production in a patient with leukemic infiltration of the kidneys.
Rats were equally divided into four groups: Control group, curcumin-treated group, EPO-induced polycythemia
group, and curcumin + EPO-induced polycythemia
Background and Objectives: Polycythemia
is a disorder characterized by raised hematocrit (HCT) level of [greater than or equal to] 0.
A diagnosis requires meeting all the following criteria:[sup] platelet (PLT) count ≥450 x 10[sup]9/L; megakaryocyte proliferation with large and mature morphology; not meeting the WHO criteria for chronic myeloid leukemia, polycythemia
vera, primary myelofibrosis, myelodysplastic syndromes, or other myeloid neoplasm; demonstration of JAK2V617F or other clonal markers or no evidence of reactive thrombocytosis.
In the 2008 World Health Organization classification system, the category of MPNs includes chronic myelogenous leukemia; chronic neutrophilic leukemia; polycythemia
vera; primary myelofibrosis; essential thrombocythemia; chronic eosinophilic leukemia; mastocytosis; and MPN, unclassifiable; and the clinical and pathologic findings may overlap with the category of myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1.
Although those diseases, beta-thalassemia and polycythemia
vera, have opposite effects on red blood cell production, treating animals with minihepcidin helps to restore normal levels of red blood cells and reduces spleen enlargement.
Common arguments against DCC include that it causes clinical jaundice, infection, postpartum hemorrhage, polycythemia
, and that it interferes with skin-to-skin contact.