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polycythemia
(redirected from polycythemia vera)

   Also found in: Medical, Acronyms, Encyclopedia, Wikipedia 0.01 sec.
pol·y·cy·the·mi·a  (pl-s-thm-)
n.
A condition marked by an abnormally large number of red blood cells in the circulatory system.

ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.polycythemia - a disorder characterized by an abnormal increase in the number of red blood cells in the blood
blood disease, blood disorder - a disease or disorder of the blood


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According to Izraeli, a similar mutation of the JAK2 in Down syndrome and leukemia causes Polycythemia Vera, a disease common in adults that leads to the overproduction of blood.
The main area of focus for the JAK2 program has been the development of orally available JAK2 inhibitors to treat myeloproliferative disorders, which include myelofibrosis, polycythemia vera (PV) and essential thrombocythemia (ET).
Although the JAK2 mutation linked to ALL differs slightly from the defect in polycythemia vera patients, research into JAK2 inhibitors already under way for that disease could speed drug development for ALL patients with Down syndrome, Izraeli says.
 
 
 
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