Although the number of genes involved in the etiology of MS is unknown, MS is probably a polygenic disease
Type 2 diabetes mellitus is a polygenic disease
characterized by insulin resistance followed by a failure of pancreatic [beta] cells to adequately compensate for this resistance despite increased insulin secretion.
The detection and mapping of the locations of the genes predisposing to a polygenic disease
would require hundreds of thousands of DNA markers.
Many of these reported associations are not very strong and it would be logical to assume that since MTX acts on several metabolic pathways in a polygenic disease
like RA, a single genetic locus would probably be unable to adequately predict the response.
The pathogenesis of type II diabetes mellitus: a polygenic disease
The explanation formulated here is that polygenic disease
and growth regulation are not linear processes and cannot therefore be fully analyzed by a linear logic.
The genome of the cloned animal will have more harmful mutations than the parent, and Morris said this "will lead to an increased chance of impaired development, impaired function, and polygenic disease
Asthma is a complex polygenic disease
that is heavily influenced by genetic susceptibility.
We have proved for the first time that type I diabetes is a polygenic disease
," says John A.
Taken together, the findings of higher expression of SLA and LST1 genes in NTD samples highlights the immunological aspect of this polygenic disease
Because asthma is a polygenic disease
with important interactions with environmental exposures, it is necessary to think in a less reductionistic manner and to emphasize interaction and communication between epidemiologists, clinicians, and basic scientists.
Obesity is a complex polygenic disease
, requiring research into understanding the major factors and interactions among the different pathways.