M2 PHARMA-March 6, 2018-MicuRx awarded CARB-X's grant for innovative polymyxin
M2 EQUITYBITES-March 6, 2018-MicuRx awarded CARB-X's grant for innovative polymyxin
All isolates of acinetobacter baumannii (n=32) were resistant to ampicillin, ceftriaxone and ceftazidime but sensitive to polymyxin
Consumption of quinolones (ciprofloxacin) did not change and a reduction in the use of polymyxin
Most of the 1st and 2nd generation cephalosporins were resistant to biofilm producers whereas carbapenem, polymyxin
and tetracycline came out to be effective drugs against biofilm producers.
The following antibiotics were included: amoxicillin, amoxicillin-clavulanic acid (AMC), piperacillin, piperacillin-tazobactam (TZP), mezlocillin, mezlocillin-sulbactam (MSU), cefazolin, cefuroxime, ceftriaxone, cefotaxime, ceftazidime, cefoperazone, cefoperazone-sulbactam (CSL), cefepime, aztreonam, moxalactam, imipenem, meropenem, panipenem, ertapenem, gentamycin, amikacin, tetracycline, minocycline, tigecycline, ciprofloxacin, levofloxacin, nitrofurantoin, fosfomycin, polymyxin
B, and colistin.
Rapid Detection of Polymyxin
Resistance in Enterobacteriaceae
7 Neomycin S Polymyxin
B Sulphate & Bacitracin, Ocpupol Eye Oint 5gm NO 1650
Reference susceptibility testing by broth microdilution showed that the isolates had a colistin (also known as polymyxin
E) minimum inhibitory concentration (MIC) of 2 [micro]g/ml, and polymyxin
B MIC of 4 [micro]g/ml.
Adverse reactions associated with systemic polymyxin
Commonly used topical agents include bacitracin, cefazolin, ciprofloxacin, gentamycin, impenem, mupirocin, neomycin, polymyxin
, retapamulin, and benzoyl peroxide.
Ceftazidime (CAZ, 30 [micro]g), imipenem (IMP, 10 [micro]g), meropenem (MEM, 10 [micro]g), ciprofloxacin (CIP, 5 [micro]g), aztreonam (ATM, 30 [micro]g), polymyxin
B (PB, 300 units), gentamicin (GM, 10 [micro]g), vancomycin (30 [micro]g), piperacillin (PIP, 100 [micro]g), ceftriaxone (CRO, 30 [micro]g), and amikacin (AMK, 30 [micro]g) purchased from MAST, Merseyside, UK, were used, according to CLSI (Clinical Laboratory Standard Institute) recommendations and the disk diffusion method was applied to determine antibiotic susceptibility.