Members of the AID/APOBEC family of enzymes deaminate cytosine (C) to uracil (U) in the context of a polynucleotide
Patent Application Number 13/336,028 entitled, "In Vivo Polynucleotide
Delivery Conjugates Having Enzyme Sensitive Linkages.
Mark Glover, his graduate student Zahra Havali-Shahriari and post-doctoral fellow Nicolas Coquelle solved the structure of a DNA repair enzyme called polynucleotide
kinase/phosphatase, or PNKP.
6,307,039 (Method for Analyzing a Polynucleotide
Containing a Variable Sequence and a Set or Array of Oligonucleotides Thereof), 6,770,751 (Method for Analyzing a Polynucleotide
Containing a Variable Sequence and a Set or Array of Oligonudeotides Thereof) and 7,192,707 (Method for Analyzing Polynucleotide
Targets Using Tethered Oligonucleotide Probes).
It extends to antisense polynucleotide
constructs and to structures that increase the stability of antisense RNA, as well as non-human organisms containing antisense constructs, among others.
For instance, each nucleic acid that is added to a polynucleotide
can have a different conformation.
Washington, June 18 (ANI): An enzyme, called human polynucleotide
phosphorylase or hPNPaseold-35, discovered in 2003, could play a major role in preventing melanoma-the most serious type of skin cancer.
Tokyo, Japan) has patented a protein having saponin-decomposing activity, more specifically a protein which can decompose a glycoside having soyasapogenol B as an aglycone to produce soyasapogenol B, a polynucleotide
encoding such a protein, and a method of producing soyasapogenol B on a large scale using the same.
4,994,373 ("Method and Structures Employing Chemically-Labeled Polynucleotide
8,338,100 "Isolated Genomic Polynucleotide
Fragments from Chromosome 12 that Encode Human Carboxypeptidase M" is directed to the region of a genomic sequence encoding a protein associated with monocyte to macrophage differentiation.
She is a founding team member for the International Consortium for Polynucleotide
AAL was incorporated in July 2003 for product research and development in the field of nonphotolithographic arrays of polynucleotide
sequences and instruments.