One of these polysomic cases also had trisomy 7 (Figure 2, A and B).
The supernatant was hypocellular, having only 66 cells, but 3 polysomic cells were present.
UFISH in conjunction with FNA would have been able to increase the diagnostic sensitivity to 94% (49 of 52) of patients if polysomic and 0-gold UFISH results were considered positive.
Other authors (9,10) have found that when only polysomic results were considered in biliary brushing or washing specimens, the specificity was 100%.
18) demonstrated the promising role of UroVysion fluorescent in situ hybridization (FISH) in clearly differentiating patients with CIS from patients with dysplasia or reactive atypia; detecting polysomic
cells (of chromosomes 3, 7 and 17) and deletion of the 9p chromosome, which are particularly present in CIS and invasive urothelial tumors.
The incidence of polysomy of chromosome 17 varies from 10-50 per cent depending on criterion used to define the polysomic
inheritance would require different algorithms for estimating the population genetic dynamics of homosporous vascular plants.
The statistical association between Cep17 copy number, categorized as polysomic or eusomic, and ER, PgR, and Ki-67 expression, age, lymph node status, and histologic grade was assessed by using the x2 test.
1%) (3 of 177 polysomic tumors were not available for HER2/neu immunocytochemical evaluation and were discarded) and absent in 31 cases (17.
Among the polysomic cases, the differences in tumor size (T $ 2 cm/ T <2 cm) and nodal status (N+/N--) did not show statistical significance; on the other hand, the differences in histologic grade, immunoreactivity for hormone receptors, proliferative activity, HercepTest staining, and FISH results proved highly significant upon nonparametric x2 statistical analysis (Table 2).
7 8 9 10 OLYMPIC +A= MYOPICAL +B= AMBLYOPIC +L= COMPLIABLY< +T= COMPATIBLY< +D= DIPLOMACY +I= OLYMPIADIC< +E= POLYAEMIC +H= POLYHAEMIC +E= POLYEMIC +A= polyaemic> +R= POLYMERIC +F= CLYPEIFORM +T= LIPECTOMY +I= TIME POLICY< +X= COMPLEXITY< +I= IMPOLICY +S= MISPOLICY< +S= OLYMPICS +C= CYCLOPISM< +I= mispolicy> +O= POLYSOMIC
+E= POLYOECISM 11 +T= MYELOPATHIC +O= +Y= +S= CYPSELIFORM< +T= COMPOSITELY<
54) Patients with chromosome 17 polysomic
breast cancer in the absence of HER2 amplification or 3+ IHC are not candidates for targeted therapy, and they have not been considered eligible for adjuvant trastuzumab trials or trials comparing different HER2 therapies.