The Company is developing EYS606, an innovative combination product associating a DNA plasmid encoding a therapeutic protein with an injection-electroporation device, for the treatment of Non-Infectious Posterior Uveitis
plans to file a New Drug Application (NDA) for Medidur for posterior uveitis
based on six-month efficacy data for both Phase III trials.
Toxoplasmosis is the most common cause of posterior uveitis
Anterior uveitis, intermediate uveitis, posterior uveitis
, and panuveitis are the common types of uveitis; among these, anterior uveitis is the most common type of uveitis.
This report provides comprehensive information on the therapeutic development for Posterior Uveitis
Patients who had vitritis with retinitis and/or vasculitis were classified as having posterior uveitis
, and those who had anterior and posterior uveitis
at the same time were classified as having panuveitis.
A recent international expert panel suggested that anti-TNF therapy might be suitable for patients with severe, organ-threatening disease--patients with two or more relapses of posterior uveitis
per year--low visual acuity resulting from chronic cystoid macular edema, or active central nervous system disease (Rheumatology 2007;46:736-41).
Originally thought of as two separate entities, Vogt-Koyanagi disease (with severe anterior uveitis, frequent vitiligo, and poliosis) and Harada's disease (with bilateral severe posterior uveitis
, exudative retinal detachment, and slight anterior uveitis), these disorders are now thought to be a spectrum of one disease because they share clinical characteristics.
We are pleased with the progress of our lead development product, an injectable micro-insert for posterior uveitis
pSivida's lead product candidate, Medidur for the treatment of posterior uveitis
, is currently in pivotal phase III clinical trials.
pSivida's FDA-approved Retisert, licensed to Bausch & Lomb Incorporated, provides long-term, sustained drug delivery to treat posterior uveitis
Infliksimab in the treatment of refractory posterior uveitis