A highly selective, noncompetitive AMPA receptor antagonist that reduces neuronal hyperexcitation associated with seizures by targeting glutamate activity at postsynaptic
AMPA receptors, it is approved in countries around the world as an adjunctive therapy for the treatment of partial-onset seizures with or without secondarily generalized seizures, and primary generalized tonic-clonic seizures in patients with epilepsy 12 years of age and older.
Motoneuron-derived agrin is secreted from nerve terminals into the synaptic cleft and leads to clustering and synthesis of postsynaptic
AChRs through activation of the postsynaptic
Such drugs are thought to antagonize the postsynaptic
dopamine receptors in the corpus striatum; thus, postsynaptic
cholinergic receptors are activated in this way, leading to the development of signs and symptoms (7).
Axonal processes recognize their target postsynaptic
dendrites using multiple molecular keys and start to differentiate synaptic structures.
The mechanism by which haloperidol reduces the symptoms could be related to blockade of postsynaptic
dopamine receptors in the brain, ultimately reducing stimulation of vomiting at the medullary level (Jones & Abernathy, 2016).
activation of alpha-2 receptors in CNS inhibits sympathetic activity and thus reduces blood pressure and heart rate.
Second, we will determine the postsynaptic
impact of cholinergic and dopaminergic neurons by manipulating them both separately and simultaneously while recording consequential changes in cortical neuronal activity and learning behaviour.
GABA is released from presynaptic neurons and binds to postsynaptic
We chose the neurons of the primary somatosensory cortex as the target area to investigate the effects of ketamine on the glutamate receptors-related spontaneous excitatory postsynaptic
currents (sEPSCs) and miniature excitatory postsynaptic
currents (mEPSCs) in rats.
2+] in presynaptic terminals triggers glutamate exocytosis, followed by postsynaptic
neuron excitation, which induces an increase in intracellular [Ca.
But, glucose sensing in the VMN is not so simple as it seems, because it involves a complex convergence of preand postsynaptic
Methods: Field excitatory postsynaptic
potentials (fEPSPs), spontaneous excitatory postsynaptic
currents (sEPSCs) and miniature spontaneous excitatory postsynaptic
currents (mEPSCs) were recorded, by using in vitro field potential electrophysiology and whole-cell patch clamp techniques in acute hippocampal slices from rats.