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Of or relating to a substance or process, such as splicing, that occurs or is formed after transcription of RNA: posttranscriptional modification of RNA.


(ˌpoʊst trænˈskrɪp ʃə nl)

occurring after the formation of RNA from DNA but before the RNA strand leaves the nucleus.
References in periodicals archive ?
The molecular events and the number of genes directly controlled by this novel type of posttranscriptional gene silencing remain elusive.
Also significant is the fact that at posttranscriptional level, miRNA interacts with the targeted site within the 3'-UTR of the RAAS gene which in turn triggers the regulation of RAAS and the pathology of preeclampsia.
Hence, we conclude that this compound did not regulate nucleophosmin expression directly at the gene- or transcription factor level, but rather indirectly at various posttranscriptional levels.
Genetic immunization is an attractive approach to generate antibodies because native proteins are expressed in vivo with normal posttranscriptional modifications, avoiding time-consuming and costly antigen isolation or synthesis.
miRNAs are endogenous, single-stranded, short non-coding RNA sequences (~22 nucleotides) that regulate gene expression at the posttranscriptional level.
The genetic structure of the 3'-UTR could affect to posttranscriptional regulatory mechanisms (Shabalina and Spiridonov, 2004).
MicroRNAs (miRNAs) are small, 22-nucleotide non-coding RNAs with posttranscriptional regulatory roles with cleavage or translational repression of mRNAs.
Cellular processing of proteins is a complex process that includes posttranscriptional modifications, transport to and from subcellular compartments, and cleavage into mature protein.
Objective: MicroRNAs (miRNAs) are endogenous non-coding RNAs, 19-25 nucleotides in length involved in posttranscriptional regulation of gene expression in a considerable majority of mRNAs.
They discuss therapeutic approaches in the improvement of cognitive performance in Down syndrome; recent progress in the understanding of the role of genome-altering processes in the generation of mental retardation and neural phenotypes in Down syndrome and how the concept reconciles with phenotypic variability associated with aneuploidy; and intellectual disabilities, neuronal posttranscriptional RNA metabolism, and RNA-binding proteins.
Other mechanisms, such as gene mutation, methylation, or transcriptional and posttranscriptional factors, may have a role in explaining the discrepant results.
Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol.