pravastatin


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prav·a·stat·in

 (prăv′ə-stăt′n)
n.
A statin drug, C 23H36O7, that blocks the body's synthesis of cholesterol and is used in its sodium form to lower cholesterol (especially LDL) levels and to reduce the risk of heart attack and stroke in individuals with elevated risk.

[pra-, of unknown origin + -vastatin, statin suffix (from mevastatin, a statin : meva(lonic acid), precursor in the biosynthesis of cholesterol from val(eric acid) + -stat + -in).]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.pravastatin - an oral drug (trade name Pravachol) administered to reduce blood cholesterol levels; recommended after nonfatal heart attacks
lipid-lowering medication, lipid-lowering medicine, statin, statin drug - a medicine that lowers blood cholesterol levels by inhibiting HMG-CoA reductase
Translations

pravastatin

n pravastatina
References in periodicals archive ?
The primary prevention study randomized 6,595 middle-aged Scotsmen with an average baseline LDL cholesterol of 190 mg/dL to 4 years of pravastatin at 40 mg/day or placebo.
Rats given daily doses of pravastatin - sold as Pravachol - had to recognise a previously seen object and find a food reward.
The study led by scientists at the University of Bristol and, tested pravastatin and atorvostatin (two commonly prescribed statins) in rat learning and memory models.
However, the WOSCOPS (West of Scotland coronary prevention study) suggested that patients taking pravastatin had a 30% lower risk of diabetes compared with placebo.
study (Pitavastatin compaREd with praVAstatin In Lowering LDL-C in the U.
The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels.
Each participant received one of five different statins: fluvastatin (Lescol[R]), pravastatin (Mevacor[R]), rosuvastatin (Crestor[R]), simvastatin (Zocor[R]), or atorvastatin (Lipitor[R]).
Pitavastatin effectively reduced LDL-C and improved other parameters of lipid metabolism in special patient populations including the elderly(4) and patients at higher cardiovascular risk(5) - Pitavastatin was superior to pravastatin in improving parameters of lipid metabolism in elderly patients (>65 years)(4) - Pitavastatin demonstrated a gradual and sustained increase in high density lipoprotein cholesterol (HDL-C) over the long-term, supported by data from a 52 week extension study(5)
In HIV patients, treatment of LDL is complicated by the interactions of statins with HAART, and some studies have shown that atorvastatin and pravastatin may be used with ritonavir and saquinavir, but that simvastatin should be avoided (10).
The study involved patients who were taking atorvastatin, pravastatin, or simvastatin.