Our study showed that the anti-immobility effect of FRA was prevented by pretreatment of rat with PCPA, WAY100635, ketanserin, yohimbine, haloperidol, SCH23390 and sulpiride, but no prazosin
in FST, providing evidence of the participation of 5-HT1A and 5-HT2A receptor antagonist, a2-adrenoceptor antagonist, D1 and D2 receptor antagonist but not al-adrenoceptor antagonist in the antidepressant-like effect of FRA in the rat FST.
Hypertension control is maintained with other drugs (including slow-release verapamil with or without hydralazine, and including prazosin
or doxazosin) that are renin and aldosterone neutral.
Amitraz-induced glucose intolerance in rats: antagonism by yohimbine but not by prazosin
The antidepressant-like effect of gulvel was significantly reversed on tail suppression test by pretreatment of Swiss young albino mice with prazosin
(an alpha-1 adrenoceptor antagonist), sulpiride (a selective dopamine D2-receptor antagonist), p-chlorophenylalanine (PCPA--a serotonin synthesis inhibitor) and baclofen (GABA-B agonist).
Drugs such as prazosin
, doxasoxin and terazosin are used to treat hypertension because they induce peripheral vasodilation, leading to a decrease in TPR.
Management of scorpion sting: Prazosin
Efficacy and safety of Minipress XL, a new once-a-day formulation of prazosin
Incubation of brain slices with different neurotransmitter antagonists, such as atropine, prazosin
, or L-2-amino-4-phosphonobutanoate (L-AP4) did not modify the increase in [3H]InsP formation produced by alpha GPC, suggesting that the effect is not mediated by an increased availability of a specific neurotransmitter.
, an [alpha]-1 adrenergic antagonist that is effective in treating posttraumatic stress disorder (PTSD), has shown preliminary efficacy in a small pilot study with 24 alcohol-dependent patients without PTSD (Simpson et al.
5-10 mg/day of drugs blocker Diltiazem 60-120 mg (nifedipine is bid-tid most-studied Diltiazem SR 120-300 mg/day agent); placebo-controlled trials indicate benefits; diltiazem is probably not as effective as dihydropyridines ARB Losartan 25-100 mg/day Has demonstrated positive clinical benefits in both primary and secondary Raynaud's ACE Captopril Various Very little inhibitor Enalapril evidence to support Lisinopril use of these agents; use only as alternative to first-line therapies SSRI Fluoxetine 20-40 mg/day One placebo-controlled trial has indicated benefit Alpha- Prazosin
1-5 mg bid Only limited blocker benefits demonstrated; efficacy may be transient Nitrate Topical 0.
EFFICACY OF PRAZOSIN
IN THE EXTINCTION AND RECONSOLIDATION OF CONTEXTUAL FEAR CONDITIONING IN RATS.
Even after three years on the market (1990-1992) generic Prazosin
had yet to reach a sixty percent quantity share of the market, despite the fact that the price of the generic was at that point on average seventy-five percent less than that of its brand-name counterpart.