Areas with higher concentration of SHH developed into posterior or postaxial structures, whereas lower concentrations developed into more anterior or preaxial structures.
The incidence of preaxial polydactyly is reported to be as high as 1 in 3000 births.
The spectrum of GCPS overlaps with that of the so-called non-syndromic preaxial
Polydactylies such as preaxial
Polydactyly type 4 (11).
Furthermore, variable anomalies of the hands and feet, such as duplicated terminal phalanx of the thumb, triphalangeal thumb (long finger-like thumb with three phalanges instead of two), preaxial polydactyly (thumb duplication), syndactyly (fusion) of the second and third digits, and fifth finger clinodactyly (curving of the fifth finger towards the fourth) have also be seen in cases with LADD [Guven et al.
A number of reports have detailed anomalies of the hands and feet, such as duplicated terminal phalanx of the thumb, triphalangeal thumb, preaxial polydactyly, syndactyly of the second and third digits, and fifth finger clinodactyly [Poznanski et al.
Congenital tibial aplasia with preaxial
polydactyl: soft tissue anatomy as a clue to teratogenesis.
Other reports indicated that mutation in the above chromosome regions resulted in human preaxial
polydactyly, mouse Hx, Hm and Ssq limb abnormality, and chicken polydactyly.
2) : preparatory or prerequisite to: premedical b : in advance: beforehand: precancel prepay 2 : in front of: anterior to: preaxial
The infant had multiple craniofacial and preaxial
skeletal anomalies and was diagnosed with Nager's syndrome.
The skeletal plan of the rhipidistian Eusthenopteron consisted of an axial series of bones, each of which articulated with a preaxial