presynaptically


Also found in: Medical.

presynaptically

(ˌpriːsɪˈnæptɪkəlɪ)
adv
(Microbiology) in a presynaptic manner
References in periodicals archive ?
10) Although the mechanism of action of gabapentin is not completely understood, the drug likely binds to the [alpha]2[delta] subunit of voltage-gated calcium channels that then act presynaptically to decrease the release of excitatory neurotransmitters.
Pregabalin works presynaptically on overactive calcium channels and can reduce the symptoms of neuropathic pain.
The neurotoxins act presynaptically, initially releasing acetylcholine, followed by an interference with or blockade of its release.
1A] receptors are located both presynaptically (as so-called somatodendritic receptors on the cell bodies of the 5-HT neurons in the diverse raphe nuclei in the brain stem) and postsynaptically in discrete brain regions, including the cortex, amygdala and the hippocampus (Glaser and De Vry 1992; Hamon 1997).
Botulinum toxin acts presynaptically at cholinergic nerve terminals by preventing acetylcholine exocytosis and release and causes muscle paresis which can last for two to three months (1,2).
We used PPF to test the hypothesis that TDE, galanthamine and ACh reduce synaptic responses by presynaptically depressing glutamatergic release.
presynaptically, in the synaptic region of the postsynaptic cell, or in the membrane more distant from the synapse [i.
Tetrabenazine decreases the jerky, involuntary movements of chorea in Huntington's disease by reversibly inhibiting vesicular monoamine transporter 2, depleting monoamines presynaptically and depleting dopamine preferentially over norepinephrine and/or 5-hydroxytryptamine, according to its manufacturer, Prestwick Pharmaceuticals Inc.
The excess glutamate feeds back presynaptically and inhibits normal release of glutamate, leading to memory problems and impairment in the ability to think clearly," Dr.
beta]--neurexin is located in axons and interacts presynaptically with CASK, a multidomain scaffolding protein that organizes the presynaptic space and emits signals to the actin cytoskeleton via protein 4.