prion


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Related to prion: Prion disease, Prion protein

pri·on

(prī′ŏn′, prē′-)
n.
A protein particle that is the agent of infection in a variety of neurodegenerative diseases, including bovine spongiform encephalopathy, Creutzfeldt-Jakob disease, and scrapie. Prions are the only known infectious agents that do not contain DNA or RNA. They derive from a normal body protein that becomes irreversibly misfolded, and they proliferate in the body, possibly by acting as a template for further protein misfolding.

[Alteration of pro(teinaceous) in(fectious particle).]

prion

(ˈpraɪən)
n
(Animals) any of various dovelike petrels of the genus Pachyptila of the southern oceans that have a serrated bill
[C19: New Latin, from Greek priōn a saw]

prion

(ˈpriːɒn)
n
(Microbiology) a protein in the brain, an abnormal form of which is thought to be the transmissible agent responsible for certain spongiform encephalopathies, such as BSE, scrapie, Creutzfeldt-Jakob disease, and kuru
[C20: altered from pro(teinaceous) in(fectious particle)]

pri•on

(ˈpri ɒn, ˈpraɪ-)

n.
a tiny proteinaceous particle, likened to viruses and viroids, but having no genetic component, thought to be an infectious agent in bovine spongiform encephalopathy, Creutzfeldt-Jakob disease, and similar encephalopathies.
[1980–85; pr (oteinaceous) + i (nfectious) + -on1]

pri·on

(prē′ŏn)
A particle composed of protein, similar to a virus but lacking DNA or RNA. Prions are thought to be the agent of infection of some diseases of the nervous system.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.prion - (microbiology) an infectious protein particle similar to a virus but lacking nucleic acid; thought to be the agent responsible for scrapie and other degenerative diseases of the nervous system
microbiology - the branch of biology that studies microorganisms and their effects on humans
subatomic particle, particle - a body having finite mass and internal structure but negligible dimensions
Translations
prioni
プリオン
프리온

prion

nPrion nt; prion proteinPrion-Protein nt

prion

n prion or prión m
References in periodicals archive ?
Familial TSE are invariably associated with PrPC mutations, and the dearth of genetic modifiers has hampered our understanding of prion diseases.
But evolution had already devised a cure for the prion disease, a new study shows.
Equally important, the researchers say, this study may hold promise against human diseases suspected to be caused by prion infections, such as Creutzfeldt-Jakob disease, kuru, familial insomnia, and variably protease-sensitive prionopathy.
This exciting advance, the culmination of decades of studies on prion diseases, markedly improves on available diagnostic tests for CJD that are less reliable, more difficult for patients to tolerate, and require more time to obtain results," says Anthony S.
Prion diseases are rare fatal neurodegenerative conditions that affect humans and animals.
Prions, however, are simply misfolded proteins that have the remarkable ability to induce properly folded proteins to adopt a misfolded, prion state.
Transmissible Spongiform Encephalopathies (TSE) are chronic degenerative neurological diseases characterized by the accumulation in the brain of an abnormal form of a cellular glycoprotein known as PrP or prion protein (proteinaceous infectious particle).
Washington, April 4 ( ANI ): American researchers have for the first time identified a pair of drugs already approved for human use that effectively acts against prion disease.
They then tested whether infectious prion proteins retained the ability to misfold normal proteins in vitro.
The effectiveness of low-temperature STERRAD(R) technology against the prion threat confirmed that is possible to eliminate these deadly pathogens while helping to preserve the integrity of medical devices, including heat sensitive surgical instruments," said Dr.
Our data on prion structure is an important step toward understanding prion infection," Stubbs said.
of Melbourne, Australia) assembles a collection of protocols from 13 different laboratories in five countries covering basic science and diagnostic areas of prion research.