prion


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Related to prion: Prion disease, Prion protein

pri·on

(prī′ŏn′, prē′-)
n.
A protein particle that is the agent of infection in a variety of neurodegenerative diseases, including bovine spongiform encephalopathy, Creutzfeldt-Jakob disease, and scrapie. Prions are the only known infectious agents that do not contain DNA or RNA. They derive from a normal body protein that becomes irreversibly misfolded, and they proliferate in the body, possibly by acting as a template for further protein misfolding.

[Alteration of pro(teinaceous) in(fectious particle).]

prion

(ˈpraɪən)
n
(Animals) any of various dovelike petrels of the genus Pachyptila of the southern oceans that have a serrated bill
[C19: New Latin, from Greek priōn a saw]

prion

(ˈpriːɒn)
n
(Microbiology) a protein in the brain, an abnormal form of which is thought to be the transmissible agent responsible for certain spongiform encephalopathies, such as BSE, scrapie, Creutzfeldt-Jakob disease, and kuru
[C20: altered from pro(teinaceous) in(fectious particle)]

pri•on

(ˈpri ɒn, ˈpraɪ-)

n.
a tiny proteinaceous particle, likened to viruses and viroids, but having no genetic component, thought to be an infectious agent in bovine spongiform encephalopathy, Creutzfeldt-Jakob disease, and similar encephalopathies.
[1980–85; pr (oteinaceous) + i (nfectious) + -on1]

pri·on

(prē′ŏn)
A particle composed of protein, similar to a virus but lacking DNA or RNA. Prions are thought to be the agent of infection of some diseases of the nervous system.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.prion - (microbiology) an infectious protein particle similar to a virus but lacking nucleic acid; thought to be the agent responsible for scrapie and other degenerative diseases of the nervous system
microbiology - the branch of biology that studies microorganisms and their effects on humans
subatomic particle, particle - a body having finite mass and internal structure but negligible dimensions
Translations
prioni
プリオン
프리온

prion

nPrion nt; prion proteinPrion-Protein nt

prion

n prion or prión m
References in periodicals archive ?
Familial human prion diseases are passed within families and are associated with 34 known prion protein mutations.
Experts say this marks a significant milestone in quest to better understand prion diseases in people, and could eventually aid the development of new therapies.
Prion Biology: A Subject Collection From Cold Spring Harbor Perspectives in Biology
Chronic wasting disease (CWD) is a contagious prion disease of cervids that is spreading globally.
and colleagues tested plant proteins for prion power by swapping bits of them into yeast prions.
A prion disease called Bovine Spongiform Encephalopathy (BSE) is endemic to cows.
This exciting advance, the culmination of decades of studies on prion diseases, markedly improves on available diagnostic tests for CJD that are less reliable, more difficult for patients to tolerate, and require more time to obtain results," says Anthony S.
Prions, however, are simply misfolded proteins that have the remarkable ability to induce properly folded proteins to adopt a misfolded, prion state.
Transmissible Spongiform Encephalopathies (TSE) are chronic degenerative neurological diseases characterized by the accumulation in the brain of an abnormal form of a cellular glycoprotein known as PrP or prion protein (proteinaceous infectious particle).
Human prion disease falls within the transmissible spongiform encephalopathy (TSEs) category of diseases (Concise Medical Dictionary 2002), which are all closely related and are currently fatal neurodegenerative disorders.
Washington, April 4 ( ANI ): American researchers have for the first time identified a pair of drugs already approved for human use that effectively acts against prion disease.
They then tested whether infectious prion proteins retained the ability to misfold normal proteins in vitro.