is a uricosuric agent and an alternative to allopurinol.
Cidofovir 80 mg weekly was given with probenecid
on day 15 for 3 weeks when her creatinine level failed to improve.
Drugs such as allopurinol and probenecid
are typically used to help reduce uric acid levels, but the side effects can include breathing difficulties, unusual bleeding, vomiting, nausea, severe rash--and even death.
Anti-hyperuricemic drugs, such as allopurinol and probenecid
are demonstrated to produce adverse effects such as hypersensitivity and agranulocytosis (Bardin 2004; Harris et al.
Other masking agents: epitestosterone, probenecid
, alpha-reductase inhibitors, plasma expanders (e.
The ACR guidelines recommend pegloticase as third-line urate-lowering therapy in patients who are not at target despite maximum-dose therapy with a xanthine oxidase inhibitor plus second-line therapy with probenecid
, losartan, or fenofibrate.
If you have recurring gout, you may need life-long treatment with preventative drugs such as allopurinol, to reduce the production of uric acid, or probenecid
, to increase the excretion of uric acid.
Some substances are actively reabsorbed from the urinary filtrate and drugs can be used to inhibit this process: the drug probenecid
, used to treat gout, inhibits the reabsorption of uric acid.
58) They note, though, that some experts consider 10 days of intramuscular penicillin equivalent to intravenous therapy and that the CDC sanctions daily intramuscular penicillin if given with oral probenecid
There are currently five drugs that can be used to treat gout: allopurinol (Zyloprim), colchicine (Colcrys), febuxostat (Uloric), pegloticase (Krys-texxa), and probenecid
Note that probenecid
is contraindicated in kidney disease and when a history of kidney stones is present.
also is an FDA-approved therapeutic for gout.