procarbazine


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pro·car·ba·zine

 (prō-kär′bə-zēn)
n.
A potent antineoplastic drug, C12H19N3O, used in its hydrochloride form in combination with other drugs to treat advanced Hodgkin lymphoma.

procarbazine

(prəʊˈkɑːbəˌziːn)
n
(Pharmacology) a drug used in the treatment of cancer, esp lymphomas
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.procarbazine - an antineoplastic drug used to treat Hodgkin's disease
antineoplastic, antineoplastic drug, cancer drug - any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function
Translations

procarbazine

n procarbazina
References in periodicals archive ?
Health-related quality of life in patients treated with temozolomide versus procarbazine for recurrent glioblastoma multiforme.
sup][15] Second, ABVD has been widely used in clinical practice as a more effective treatment regimen over mechlorethamine, Oncovin (vincristine), procarbazine, and prednisone.
The effect of cyclophosphamide and procarbazine combination on sperm count and hormone levels (FSH) was significant.
The drugs include procarbazine, lumostine, and vincristine.
Antibiotics Doxyrubicin 0 0 Mitomycin C + + + + + + Miscellaneous Dacarbazine + + Hydroxyurea 0 + Procarbazine + 0 Activity against indicated type of organism Antineoplastic Anaerobic Agent bacteria Yeasts Alkylating agents Carmustine 0 [+ or -] Chlorambecil + + Neoplatin ND 0 No activity shown by busulphan, cyclophosphamide, dibromomannitol, and melphalan.
Previous case reports have described treatment with vincristine, lomustine, and prednisone, (4) vincristine alone, (12) and procarbazine, CCNU, and vincristine.
The patient was treated with five cycles of BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone) chemotherapy.
For chemotherapy ABVD (Adriamycin, Bleomycin, Vinblastine, Deticene) was used in 32 patients, ABVD + COPP (Cyclophosphamid, Vincristine, Procarbazine, Prednisone) was used in 3 patients, OPPA (Vincristine, Prednisone, Procarbazine, Adriamycin) + COPP was used in 2 patients, COPP+ABV was used in 3 patients and ARA-C/VP-16 + COPP/ABV + CHOP (Cyclophosphamid, Adriamycin, Vincristine, Prednisone) was used in 1 patient.
The product is intended to treat adult patients that have been recently diagnosed with glioblastoma multiforme, concomitantly with radiotherapy and then as maintenance treatment and also refractory anaplastic astrocytoma patients whose disease has progressed on a drug regimen containing nitrosourea and procarbazine.
The management consisted of urgent establishment of ABVD (adriamycin, bleomycin, vinblastine, dacarbazine) chemotherapy intensified by BEACOPP (bleomycin, etoposide, adriamycin, cyclophosphamide, vincristine=oncovin, procarbazine, prednisone) chemotherapy.
Alkyl-ating chemotherapeutic agents, such as procarbazine and/or cyclophosphamide, cause prolonged azoospermia in 90%-100H of men and premature ovarian failure (POP) in 5%-25% of younger women under 30 years old; however, the risks are low with radiotherapy alone if pelvic radiation or chemotherapy with alkylating agents is not given (22).
Treatment for Hodgkin's lymphoma with MVPP (mechlorethamine, vinblastine, procarbazine and prednisolone), MOPP (mechlorethamine, vincristine, procarbazine and prednisolone) or ChIVPP (chlorambucil, vinblastine, procarbazine and prednisolone) resulted in permanent ovarian failure in 19 - 63% of cases.