The drug costs and delayed time to pregnancy mean that ovarian suppression with oral contraceptives, other progestational
agents, or gonadotropin-releasing hormone (GnRH) agonists before fertility treatment is not indicated, with the possible exception of using it prior to in vitro fertilization (IVF).
In the year in question, the editorial Progestational
compounds by Vespasiano Ramos broke the silence: the author emphasizes the therapeutic potential of sex hormones for a range of gynaecological problems (bleeding, menstrual regularization) and writes that "the field of application of these substances is huge, therefore, with, today, the emphasis being placed above all on their use in birth control.
Given that after 24 weeks, there was no change in serum estradiol levels and vaginal or endometrial atrophy, this implies no need to oppose the estrogen with a progestational
agent, although 24 weeks is certainly not the same as long-term use.
An exaggerated response of uterine mucosa to chronic progestational
stimulation during luteal phase caused by altered estrogenprogesterone receptors leads to cystic endometrial hyperplasia with excess secretions in uterine lumen (Fayrer-Hoskens et al.
Intravascular thrombosis can result from hematological disturbances as in protein S deficiency and high progestational
states in females15.
15] Oral contraceptives, progestational
agents, and gonadotropin releasing hormone analogs have been used to induce amenorrhea.
41) And, unlike some progestational
agents, there is no evidence that the LNG-IUD has any adverse effects on bone density, vaginal tone, or urinary continence.
Mechanism of action of bolandiol (19-nortestosterone-3beta,17betadiol), a unique anabolic steroid with androgenic, estrogenic, and progestational
We typically expect pregnancy to lower the activity of Endo by ending menses during pregnancy, thus decreasing the retrograde seeding of endometrium in the pelvis and by providing a progestational
environment which has been considered an effective treatment strategy for Endo.
This was equally the case regardless of whether the mother had gestational or progestational
John Rock, questions regarding the valid use of progestational
steroids are raised, and moralists see the drugs as valid to use for therapeutic reasons, but not for contraception.
But the randomized trials with 6- to 12-month follow-up clearly show that any modest benefit achieved in terms of weight gain takes 2-3 months of therapy And megestrol acetate is a progestational
agent associated with increased risk of thrombotic events and a possible increase in mortality.