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An inactive compound that is converted by enzymes into a biologically active hormone.
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Because all conventional BNP immunoassays cross-react with proBNP (12), BNP measurements actually reflect the total concentration of both immunoreactive forms, the bioactive BNP and the intact prohormone, proBNP.
ROME -- N-terminal prohormone brain natriuretic peptide level provides a simple, previously untapped, powerful predictor of cardiovascular risk in arthritis patients on long-term NSAID therapy, according to a large prospective study.
Greer said, "Vitamin D is a prohormone that acts directly on cells to promote gene transcription.
PCT, the prohormone of calcitonin, can be produced by numerous cell types and organs after proinflammatory stimulation, especially when caused by bacterial infection, making PCT an ideal indicator of systemic bacterial infection and sepsis.
Furthermore, patients with dyspnea had higher concentrations of N-terminal prohormone brain natriuretic peptide (NT-proBNP) [median, interquartile range (IQR), 5598 (1855--15215 ng/L] compared to patients with typical chest pain (median, IQR, 375, 174--1955 pg/mL, P < 0.
Although this peptide is unstable, this novel assay detects the corresponding prohormone fragment: the Mid-Regional pro-Atrial Natriuretic Peptide (MR-proANP).
B-type natriuretic peptide (BNP) [4] and the amino terminal fragment of the prohormone BNP (NT-proBNP) appear to provide prognostic information in individuals following an acute coronary syndrome (ACS) (7).
The studies show that ILCs derived from hESCs express the pancreatic hormones insulin, glucagon and C-peptide, as well as prohormone convertase 1/3 and 2, enzymes normally expressed in mature islets.
Therefore, a novel pharmacological target maybe enzymes (such as corin) that regulate the maturation of the prohormone proBNP into the active hormone (i.
org), and on April 15, 2008 the research paper "Complementary Roles for Biomarkers of Biomechanical Strain ST2 and N-Terminal Prohormone B-Type Natriuretic Peptide in Patients with ST-Elevation Myocardial Infarction" was published in the journal Circulation, (http://circ.
fasting plasma glucose (diabetes), creatinine (renal function), N-terminal prohormone of brain natriuretic peptide (NT-pro BNP) (myocardial dysfunction)] as well as electrocardiogram, echocardiography, and spirometry (32).
PCT is the prohormone of calcitonin and is not normally present in the bloodstream of a healthy individual.