Pulmonary edema complicating prostacyclin
therapy in pulmonary hypertension associated with scleroderma: A case of pulmonary capillary hemangiomatosis.
1981) Spectral evidence for the cytochrome P450 nature of prostacyclin
The global scleroderma diagnostics and therapeutics market segmentation is based on indication (localized, systemic), test type (blood tests, electrocardiogram and echocardiogram, imaging techniques, pulmonary function tests, skin biopsy), drug class (calcium channel blockers, chelating agents, corticosteroids, endothelin receptor agonists, immunosuppressive agents, PDE-5 inhibitors, prostacyclin
analogues, ACE inhibitors, H2 blockers, proton pump inhibitors).
Many promising newer therapies like prostacyclin
analogue, endothelin receptor antagonist, phosphodiesterase inhibitors improve clinical function and haemodynamic measures.
James, Roles of cyclooxygenase (COX)-1 and COX-2 in prostanoid production by human endothelial cells: selective up-regulation of prostacyclin
synthesis by COX-2, The Journal of Immunology, 167(5), 2831-2838 (2001).
Effect of curcumin on platelet aggregation and vascular prostacyclin
Estrogen a receptors are mainly present on vessels endothelial cells therefore when there are less a receptors there may be less NO and prostacyclin
produced that may increase risks of thromboembolism in premenopausal women.
Prostanoids are drugs that mimic prostacyclin
, a strong endogenous vasodilator (Tartavoulle, 2011).
13) For patients unwilling to undergo pregnancy termination, there are data showing successful use of PAH-specific medications like sildenafil, and prostacyclin
These include the discovery of the vasodilator prostacyclin
, that of endothelium-derived relaxing factor and its identification as nitric oxide (NO).
synthase is the enzyme responsible for the production of the eicosanoid vasodilator prostacyclin
5) In the CV system, prostacyclin
is synthesized by COX-2.