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protamine

   Also found in: Medical, Encyclopedia, Wikipedia 0.01 sec.
pro·ta·mine  (prt-mn, -mn) also pro·ta·min (-mn)
n.
Any of a group of simple proteins found in fish sperm that are strongly basic, are soluble in water, are not coagulated by heat, and yield chiefly arginine upon hydrolysis. In purified form, they are used in a long-acting formulation of insulin and to neutralize the anticoagulant effects of heparin.

protamine [ˈprəʊtəˌmiːn]
n
(Life Sciences & Allied Applications / Biochemistry) any of a group of basic simple proteins that occur, in association with nucleic acids, in the sperm of some fish
[from German: see proto-, amine]
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.protamine - a simple protein found in fish sperm; rich in arginine; simpler in composition than globulin or albumin; counteracts the anticoagulant effect of heparin
simple protein - a protein that yields only amino acids when hydrolyzed


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This occurs when heparin reappears in the blood stream a few hours following post-operative protamine administration.
Gabor Nemesdy, who was a named defendant, opined that ordinarily the chest would have been closed a half hour to an hour after Protamine was administered, which in this case was at about 1:08 p.
When a protein called protamine is attached to a short-acting insulin, it becomes NPH (Neutral Protamine Hagedorn [N]), an intermediate-acting insulin.
 
 
 
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