protamine


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Related to protamine: protamine insulin

pro·ta·mine

 (prō′tə-mēn′, -mĭn) also pro·ta·min (-mĭn)
n.
Any of a group of arginine-rich proteins that bind to and package DNA in the sperm nucleus. Protamines are used in long-acting formulations of insulin and to neutralize the anticoagulant effects of heparin.

protamine

(ˈprəʊtəˌmiːn)
n
(Biochemistry) any of a group of basic simple proteins that occur, in association with nucleic acids, in the sperm of some fish
[C19: from German: see proto-, amine]

prot•a•mine

(ˈproʊ təˌmin, prɒˈtæm ɪn)

n.
any of a group of arginine-rich, strongly basic proteins that are not coagulated by heat.
[1870–75]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.protamine - a simple protein found in fish sperm; rich in arginine; simpler in composition than globulin or albumin; counteracts the anticoagulant effect of heparin
simple protein - a protein that yields only amino acids when hydrolyzed
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References in periodicals archive ?
Tenders are invited for Insulin Aspart 30 Percent With Protamine Cryst Aspart 70 Percent ,100 Iu/Ml 3Ml Disp Pen Brand-Novomix 30 Flex Pen
Mismanagement of heparin anticoagulation and subsequent reversal with protamine sulfate is a common contributor of coagulopathic bleeding in the perioperative setting.
One intravenous (IV) dose of protamine sulphate can neutralise about 60-75% of the anti-Xa activity.
Protamine is an important drug that is used as an anti-heparin agent to prevent blood coagulation during cardiovascular surgeries.
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Recent studies have indicated that protamine deficiency and sperm DNA damage are associated with poor ART outcomes (10, 11).
Frank, a co-investigator at the National Institutes of Health (NIH), had previously demonstrated that the combination of ferumoxides with protamine sulfate showed promise in labeling NSC';s for this purpose.
62), (64) Bu model toroid stkistirilmastyla ve toroidlerin istiflenmesiyle protamine bagli DNA'nin hasardan korunurken, linker (baglayict) bolgelerin ve histona bagh DNA bolgelerinin endonukleazlarin olusturdugu DNA hasanna maruz kalcligini gostermektedir.
Heparin was neutralised with protamine in a 1:1 ratio and an additional 100 mg of protamine was cautiously administered over 20 minutes to achieve an activated clotting time of 165 seconds, which was considered acceptable in the absence of surgical bleeding.
Although the titrations performed in this study involved manual addition of protamine to the blood samples, resulting in a rather lengthy assay time (3 min/ titration point; 30-45 min for entire manual titration, depending on the number of points), preliminary attempts were made also to automate such titrations by using a syringe pump for continuous protamine infusion into heparinized samples.