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Mismanagement of heparin anticoagulation and subsequent reversal with protamine
sulfate is a common contributor of coagulopathic bleeding in the perioperative setting.
One intravenous (IV) dose of protamine
sulphate can neutralise about 60-75% of the anti-Xa activity.
is an important drug that is used as an anti-heparin agent to prevent blood coagulation during cardiovascular surgeries.
It covers the historical sales trend of injectables for categories such as Diabetes, Vaccines, Sex Hormones & Antagonist in Malign Disease, Anticoagulants & Protamine
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Methods of characterizing the individual phases of blood coagulation: prothrombin time; thrombin time; clotting fibrinogen; antithrombin III (AT III), protamine
sulfate test, ethanol test.
Sulfate (CAS 53597-25-4) Market Research Report presents comprehensive data on protamine
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Recent studies have indicated that protamine
deficiency and sperm DNA damage are associated with poor ART outcomes (10, 11).
Frank, a co-investigator at the National Institutes of Health (NIH), had previously demonstrated that the combination of ferumoxides with protamine
sulfate showed promise in labeling NSC';s for this purpose.
62), (64) Bu model toroid stkistirilmastyla ve toroidlerin istiflenmesiyle protamine
bagli DNA'nin hasardan korunurken, linker (baglayict) bolgelerin ve histona bagh DNA bolgelerinin endonukleazlarin olusturdugu DNA hasanna maruz kalcligini gostermektedir.
Heparin was neutralised with protamine
in a 1:1 ratio and an additional 100 mg of protamine
was cautiously administered over 20 minutes to achieve an activated clotting time of 165 seconds, which was considered acceptable in the absence of surgical bleeding.
Although the titrations performed in this study involved manual addition of protamine
to the blood samples, resulting in a rather lengthy assay time (3 min/ titration point; 30-45 min for entire manual titration, depending on the number of points), preliminary attempts were made also to automate such titrations by using a syringe pump for continuous protamine
infusion into heparinized samples.