protamine


Also found in: Thesaurus, Medical, Encyclopedia, Wikipedia.
Related to protamine: protamine insulin

pro·ta·mine

 (prō′tə-mēn′, -mĭn) also pro·ta·min (-mĭn)
n.
Any of a group of arginine-rich proteins that bind to and package DNA in the sperm nucleus. Protamines are used in long-acting formulations of insulin and to neutralize the anticoagulant effects of heparin.

protamine

(ˈprəʊtəˌmiːn)
n
(Biochemistry) any of a group of basic simple proteins that occur, in association with nucleic acids, in the sperm of some fish
[C19: from German: see proto-, amine]

prot•a•mine

(ˈproʊ təˌmin, prɒˈtæm ɪn)

n.
any of a group of arginine-rich, strongly basic proteins that are not coagulated by heat.
[1870–75]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.protamine - a simple protein found in fish sperm; rich in arginine; simpler in composition than globulin or albumin; counteracts the anticoagulant effect of heparin
simple protein - a protein that yields only amino acids when hydrolyzed
Mentioned in ?
References in periodicals archive ?
Tenders are invited for Supply of insulin astart (r-dna origin) 30% as soluble and 70% as insulin aspart protamine crytal
The antidotes available in the market include vitamin K, protamine, and prothrombin complex concentrates, which reverse the action of warfarin and heparin.
The former company had its blood pressure drug Caduet added, while the latter had two products added to the list - a cancer injection sold as Alimta, and a diabetes injection insulin lispro protamine, branded as Humalog.
Basal insulin analogs are more likely to provide 24-hour coverage with once-daily dosing than neutral protamine Hagedorn (NPH) insulin.
Mismanagement of heparin anticoagulation and subsequent reversal with protamine sulfate is a common contributor of coagulopathic bleeding in the perioperative setting.
Protamine is an important drug that is used as an anti-heparin agent to prevent blood coagulation during cardiovascular surgeries.
Objective: To determine the effectiveness of local protamine in reducing post-operative blood loss compared to local tranexamic acid.
Recent studies have indicated that protamine deficiency and sperm DNA damage are associated with poor ART outcomes (10, 11).
Frank, a co-investigator at the National Institutes of Health (NIH), had previously demonstrated that the combination of ferumoxides with protamine sulfate showed promise in labeling NSC';s for this purpose.
62), (64) Bu model toroid stkistirilmastyla ve toroidlerin istiflenmesiyle protamine bagli DNA'nin hasardan korunurken, linker (baglayict) bolgelerin ve histona bagh DNA bolgelerinin endonukleazlarin olusturdugu DNA hasanna maruz kalcligini gostermektedir.
These highly specialized proteins can be classified into three major types: histone type (H-type), protamine-like type (PL-type), and protamine type (P-type).