protease


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Related to protease: Protease inhibitors

pro·te·ase

 (prō′tē-ās′, -āz′)
n.
Any of various enzymes, including the endopeptidases and exopeptidases, that catalyze the hydrolytic breakdown of proteins. Also called peptidase.

protease

(ˈprəʊtɪˌeɪs)
n
(Biochemistry) any enzyme involved in proteolysis
[C20: from protein + -ase]

pro•te•ase

(ˈproʊ tiˌeɪs, -ˌeɪz)

n.
any of a group of enzymes that catalyze the hydrolytic degradation of proteins or polypeptides to smaller amino acid polymers.
[1900–05; prote (in) + -ase]

pro·te·ase

(prō′tē-ās′)
Any of various enzymes that bring about the breakdown of proteins into peptides or amino acids by hydrolysis. Pepsin is an example of a protease.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.protease - any enzyme that catalyzes the splitting of proteins into smaller peptide fractions and amino acids by a process known as proteolysis
caspase - any of a group of proteases that mediate apoptosis
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
angiotensin converting enzyme, angiotensin-converting enzyme, ACE - proteolytic enzyme that converts angiotensin I into angiotensin II
plasminogen activator, urokinase - protease produced in the kidney that converts plasminogen to plasmin and so initiates fibrinolysis
renin - a proteolytic enzyme secreted by the kidneys; catalyzes the formation of angiotensin and thus affects blood pressure
Translations

protease

n proteasa
References in periodicals archive ?
LOUIS, July 15, 2015 /PRNewswire/ -- Of the three classes of animal feed enzymes -- non-starch polysaccharides, proteases and phytases -- the protease enzymes are the new kid on the block.
The enzymes which are very specific to protein hydrolysis are protease enzymes and they are classified under the hydrolases group.
These bacteria often produce high capacity of such important enzyme lipase protease and amylase and DNA polymerase, in the biotechnology and industries have many uses [5].
They discuss the groups of matrix proteases in the context of the entire degradome, different classes of proteases, specific cascade systems, and single proteolytic components with defined roles in the extracellular matrix, and their role in health and disease; the fibrinolytic system of plasminogen activation, with respect to enzymology and function in the normal organism, regulators, and the role in cancer invasion and function in ischemic stroke; and the function of the serpin-type inhibitor, protease nexin-1, and its roles in cancer.
Summary: TEHRAN (FNA)- A previously unknown serine protease forms part of the antibacterial defense arsenal.
Among different proteases alkaline protease produced by microorganisms are of main interest from a biotechnological perspective, and are investigated not only in scientific fields of protein chemistry, protein engineering but also in applied fields such as detergents, foods, tannery, pharmaceutical industry, leather industry (Kumar and Takagi, 1999), and in Silver recovery from X-ray films.
Diverse microorganisms have been investigated in an effort to obtain new isolates that are good protease producers, and in order to increase productivity and enzyme stability (BEG; GUPTA, 2003).
London, Nov 29 (ANI): A new study has demonstrated that irreversible covalent inhibition can increase selectivity, potency and duration of action, broadens applications for targeted covalent drugs to the protease gene family.
DiscoveRx Corporation (Fremont, CA) has patented methods and reagents for measuring protease activity.
Flatworms taken from mice treated with the drug showed reduced activity of the cysteine protease called cathepsin B, suggesting that this enzyme is a prime target of K11777.
In the first agreement, Medivir has outlicensed its preclinical human immunodeficiency virus (HIV) protease inhibitor project and in the second agreement provided a license for the MIV-210 polymerase inhibitor compound for HIV and hepatitis B (HBV).
Prezista (also called darunavir, or TMC-114), a new protease inhibitor active against many of the viruses resistant to other protease inhibitors, was approved by the FDA on June 23 "for the treatment of human immunodeficiency virus (HIV) infection in antiretroviral treatment-experienced adult patients, such as those with HIV-1 strains resistant to more than one protease inhibitor.