protease inhibitor


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Related to protease inhibitor: fusion inhibitor, Serine protease inhibitor

protease inhibitor

n.
1. Any of various drugs that inhibit the action of HIV protease, an enzyme necessary for replication of the HIV virus, and are used in the treatment of HIV infection.
2. Any of various substances that inhibit the action of a protease.

protease inhibitor

n
(Pharmacology) any one of a class of antiviral drugs that impair the growth and replication of HIV by inhibiting the action of protease produced by the virus: used in the treatment of AIDS
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.protease inhibitor - an antiviral drug used against HIV; interrupts HIV replication by binding and blocking HIV protease; often used in combination with other drugs
antiviral, antiviral agent, antiviral drug - any drug that destroys viruses
drug cocktail, HAART, highly active antiretroviral therapy - a combination of protease inhibitors taken with reverse transcriptase inhibitors; used in treating AIDS and HIV
Crixivan, indinavir - a protease inhibitor (trade name Crixivan) used for treating HIV
nelfinavir, Viracept - a protease inhibitor (trade name Viracept) used in treating HIV usually in combination with other drugs
Norvir, ritonavir - a protease inhibitor (trade name Norvir) used in treating HIV
Invirase, saquinavir - a weak protease inhibitor (trade name Invirase) used in treating HIV
References in periodicals archive ?
The Prezista group and the Kaletra group did not differ from each other in previous protease inhibitor use, starting CD4 count (median 232 CD4s), or starting viral load (average 20,000 copies).
The HIV protease inhibitor project is targeted at inhibition of the HIV protease enzyme and is in the pre-clinical research phase.
While Prezista was designed to overcome viral resistance to other protease inhibitors, resistance to the drug itself can develop.
The initial protease inhibitor studies clearly showed that people had to be very adherent when taking these medications.
A total of 460 HIV patients on two nucleoside reverse-transcriptase inhibitors and at least one protease inhibitor, and with plasma HIV-1 RNA levels of less than 200 copies per milliliter for at least 6 months, were randomized to be switched from a protease inhibitor to nevirapine (155 patients), efavirenz (156 patients), or abacavir (149 patients), primarily to simplify treatment regimens.
Prematurity and low birth weight were not associated with an individual protease inhibitor or with the gestational age when protease-inhibitor treatment began, Dr.
Differences in selected characteristics (sociodemographics, medication use, and clinical characteristics) between those who were and were not sexually active were assessed using chi-square tests, as were the associations of these characteristics with protease inhibitor use and with high-risk sexual behavior among persons who were sexually active.
Agouron's rhinovirus 3C protease inhibitor AG7088 is in human clinical trials for the proposed treatment of the common cold.
Among the 982 failing combinations, 742 included a protease inhibitor and 225 included a nonnucleoside.
The hepatology portfolio includes the lead HCV protease inhibitor compound, ITMN-191, a second-generation HCV protease inhibitor program, and a research program evaluating a new target in hepatology.
The trial was stopped because some of these volunteers had a poor antiviral response to TMC125; those in the control group, who were treated with protease inhibitors instead, did better in reducing viral load.