protease inhibitor


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Related to protease inhibitor: fusion inhibitor, Serine protease inhibitor

protease inhibitor

n.
1. Any of various drugs that inhibit the action of HIV protease, an enzyme necessary for replication of the HIV virus, and are used in the treatment of HIV infection.
2. Any of various substances that inhibit the action of a protease.

protease inhibitor

n
(Pharmacology) any one of a class of antiviral drugs that impair the growth and replication of HIV by inhibiting the action of protease produced by the virus: used in the treatment of AIDS
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.protease inhibitor - an antiviral drug used against HIV; interrupts HIV replication by binding and blocking HIV protease; often used in combination with other drugs
antiviral, antiviral agent, antiviral drug - any drug that destroys viruses
drug cocktail, HAART, highly active antiretroviral therapy - a combination of protease inhibitors taken with reverse transcriptase inhibitors; used in treating AIDS and HIV
Crixivan, indinavir - a protease inhibitor (trade name Crixivan) used for treating HIV
nelfinavir, Viracept - a protease inhibitor (trade name Viracept) used in treating HIV usually in combination with other drugs
Norvir, ritonavir - a protease inhibitor (trade name Norvir) used in treating HIV
Invirase, saquinavir - a weak protease inhibitor (trade name Invirase) used in treating HIV
References in periodicals archive ?
Measurement of antibacterial Activity: The antibacterial activity of purified protease inhibitor was determined by agar well diffusion method as described by Perez et al.
ACH-1625 is a once-daily protease inhibitor with broad genotypic coverage against HCV.
Major protease inhibitor mutations developed in 6 of the 28 people (21%) taking Prezista versus 20 of 56 (36%) taking Kaletra.
The HIV protease inhibitor project is targeted at inhibition of the HIV protease enzyme and is in the pre-clinical research phase.
While Prezista was designed to overcome viral resistance to other protease inhibitors, resistance to the drug itself can develop.
The initial protease inhibitor studies clearly showed that people had to be very adherent when taking these medications.
A total of 460 HIV patients on two nucleoside reverse-transcriptase inhibitors and at least one protease inhibitor, and with plasma HIV-1 RNA levels of less than 200 copies per milliliter for at least 6 months, were randomized to be switched from a protease inhibitor to nevirapine (155 patients), efavirenz (156 patients), or abacavir (149 patients), primarily to simplify treatment regimens.
Prematurity and low birth weight were not associated with an individual protease inhibitor or with the gestational age when protease-inhibitor treatment began, Dr.
Vertex's first approved product is Agenerase (amprenavir), an HIV protease inhibitor, which Vertex co-promotes with Glaxo Wellcome.
Agouron's rhinovirus 3C protease inhibitor AG7088 is in human clinical trials for the proposed treatment of the common cold.
The goal of the protease inhibitor is to stop the protease from helping to assemble a new virus.