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Related to prothrombinase: Stuart-Prower factor
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Noun1.prothrombinase - coagulation factor that is converted to an enzyme that converts prothrombin to thrombin in a reaction that depends on calcium ions and other coagulation factors
clotting factor, coagulation factor - any of the factors in the blood whose actions are essential for blood coagulation
References in periodicals archive ?
In another study, (28) IgG isolated from patients with FV inhibitors showed marked inhibition of prothrombinase complex activity.
Cytokine-dependent abortion in CBA x DBA/2 mice is mediated by the procoagulant fg12 prothrombinase [correction of prothombinase].
Murine lymphoid procoagulant activity induced by bacterial lipopolysaccharide and immune complexes is a monocyte prothrombinase.
This binding activates factor X to its active form, Xa, which in turn, binds to the co-factor FV and is bound on membrane surfaces in the presence of calcium ions to generate the prothrombinase complex.
Complement proteins C5b-9 induce vesiculation of the endothelial plasma membrane and expose catalytic surface for assembly of the prothrombinase enzyme complex.
Activated factor V stabilises the prothrombinase complex and enhances the prothrombin activation.
Targeting of venom phospholipases: The strongly anticoagulant phospholipase A2 from Naja nigricollis venom binds to coagulation factor Xa to inhibit the prothrombinase complex.
Rivaroxaban Selective No Lower (b) Low (Xarelto) inhibition of factor Xa; inhibits both free factor Xa and prothrombinase activity.
Moreover, factor Xa bound to prothrombinase is 300 000 times more active than unbound factor Xa.
Rivaroxaban has been reported to bind both to free factor Xa and to factor Xa in prothrombinase complex without the need of antithrombin as a cofactor (24).