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Related to proto-oncogene: tumor suppressor gene


 (prō′tō-ŏn′kə-jēn′, -ŏng′kə-)
A normal gene that has the potential to become an oncogene.
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Noun1.proto-oncogene - a normal gene that has the potential to become an oncogene
cistron, gene, factor - (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors"
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References in periodicals archive ?
Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand.
The proto-oncogene BCL-6 in normal and malignant B cell development.
High prevalence of activating RET proto-oncogene rearrangements in thyroid tumors from patients who had received external radiation.
BRAF (B-Raf proto-oncogene, serine/threonine kinase) in melanoma; EGFR in lung cancer.
The Evi-1 proto-oncogene encodes a transcriptional repressor activity associated with transformation.
The report provides comprehensive information on the Myc Proto-Oncogene Protein (Proto-Oncogene c-Myc or Class E Basic Helix-Loop-Helix Protein 39), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
Phosphorylation of RTKs activates the cell membrane associated SRC proto-oncogene family members that contribute to RAS GTP loading and stimulation of mitogenic signal transduction to BRAF, MEK1/2, and ERK1/2 kinases.
Takahashi, "cDNA cloning of mouse ret proto-oncogene and its sequence similarity to the cadherin superfamily," Oncogene, vol.
Proto-oncogene tyrosine-protein kinase ROS (ROS1) is a receptor tyrosine kinase of the insulin receptor family whose mutations were originally described in glioblastoma, a malignant brain tumor.
Variables within the brain and nervous system include the influence of such mediators as serotonin and other signaling molecules, such as brain-derived neurotrophic factor and the proto-oncogene c-Fos.
We investigated the binding of E2F1 at a number of promoters and identified the co-occurrence of promoter-specific H3K9 acetylation and E2F1 at the FOS promoter, a well-established proto-oncogene in HEK293T and UROtsa cells.
The regional and occasional models of proto-oncogene induction are related to gene expression regulated by neurotransmitter, which implies the transcription in physiological and pathological conditions.