Also found in: Thesaurus, Medical, Encyclopedia, Wikipedia.
Related to proto-oncogene: tumor suppressor gene


 (prō′tō-ŏn′kə-jēn′, -ŏng′kə-)
A normal gene that has the potential to become an oncogene.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.proto-oncogene - a normal gene that has the potential to become an oncogene
cistron, gene, factor - (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors"
Mentioned in ?
References in periodicals archive ?
In addition, future and ongoing clinical trials will not be limited to the targetable mutations described above and may involve mutations of other genes including ret proto-oncogene (RET) and HER2/neu.
The findings support the notion that in our patient, Burkitt lymphoma arose from the same clone as her low-grade lymphoplasmacytic lymphoma after acquisition of the MYC proto-oncogene, loss of the ETV6 tumor suppressor gene at 12p13, and loss of p53 through monosomy 17.
Earlier we determined the characteristic frequencies of forty six oncogene and fifteen proto-oncogene proteins, that characterize their common biological activity, i.
The CD 117 protein is located in the cell membrane of all cells expressing the kit proto-oncogene.
The c-erbB-2 proto-oncogene as a prognostic and predictive marker in breast cancer: A paradigm for the development of other macromolecular markers--a review.
Though it normally help cells mature, c-jun can also act as a proto-oncogene, Timblin explains.
The early discovery of the Bcl2 proto-oncogene and its subsequent linkage to apoptosis inhibition in human [Beta] cell lymphoma has led to the discovery of a number of additional structural homologs of Bcl-2 some of which function as apoptosis inducers subsequent to various cell death signals.
Targeted therapies for patients with advanced disease may be helped by the identification of the MYB-NFIB gene fusion, among others, since other targets, such as proto-oncogene C-kit, are not mutated.
Approximately 25 per cent of all MTC cases are genetic in nature, caused by a mutation in the RET proto-oncogene.
The RET proto-oncogene encodes a cell membrane receptor tyrosine kinase.