is a potentially severe infection that involves one or both kidneys.
The Targeting Antibiotic Non-susceptible Gram-negative Organisms, or TANGO 1, trial was the pivotal Phase 3 study that compared the efficacy and safety of Vabomere to piperacillin-tazobactam in the treatment of patients with cUTI and acute pyelonephritis
Key words: Drainage, UTI, Micturation, Pyelonephritis
Improved Outcomes at Late Follow-up (LFU) with Plazomicin Compared with Meropenem in Patients with Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis
(AP) in the EPIC Study
Upon US FDA approval, this will be the third indication for AVYCAZ, which was first approved for complicated intra-abdominal infections (cIAI), complicated urinary tract infections (cUTI), including pyelonephritis
, caused by designated susceptible bacteria, including certain Enterobacteriaceae and Pseudomonas aeruginosa.
The US Food and Drug Administration has approved Vabomere (meropenem and vaborbactam) for injection for the treatment of adult patients with complicated urinary tract infections, including pyelonephritis
, caused by designated susceptible Enterobacteriaceae Escherichia coli, Klebsiella pneumoniae and Enterobacter cloacae species complex, US-based biopharmaceutical company The Medicines Company (NASDAQ: MDCO) said.
They cover anatomical and physiological aspects, clinical presentation, diagnosis and treatment, infections in children, the involvement of the vaginal microbiome, asymptomatic urinary tract infections, prostatitis, pyelonephritis
, and urosepsis; reservoirs of infection, antimicrobial resistance, phylogeny, virulence, and fitness factors, including exotoxins, the structure of adhesins, adaptive mutations, and intracellular persistence, as well as other uropathogens; and host responses and emerging therapeutics, including innate immunity, sensation and pain in the bladder, and drug and vaccine development.
The usual indications are calculus disease, chronic infections, obstruction, trauma, dysplastic / atrophic kidney or renovascular hypertension due to the renal artery stenosis or severe unilateral parenchymal damage from nephrocalcinosis, pyelonephritis
, reflux or congenital dysplasia.
Bacterial nephritis has a wide spectrum ranging from acute pyelonephritis
(APN) to renal abscess and emphysematous pyelonephritis
(EPN) is a rare infectious disease, of which risk factors are poorly controlled diabetes mellitus, immunosuppression, and urinary tract obstruction.
5) It is hypothesized that incomplete bladder emptying may facilitate an environment for bacteria growth and that VUR allows the retrograde flow of infected urine into the upper urinary tracts causing pyelonephritis
and subsequent renal scarring.
results when a UTI progresses to involve the upper urinary system including kidneys and ureters.