pyrimidine


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py·rim·i·dine

 (pī-rĭm′ĭ-dēn′, pĭ-)
n.
1. A single-ringed, crystalline organic base, C4H4N2, that is the parent compound of a large group of biologically important compounds.
2. Any of a group of substituted derivatives of pyrimidine, including the nitrogen bases uracil, cytosine, and thymine, which are components of nucleic acids. Barbiturates and certain other drugs are also pyrimidines.

[Alteration of pyridine.]

pyrimidine

(paɪˈrɪmɪˌdiːn)
n
1. (Elements & Compounds) a liquid or crystalline organic compound with a penetrating odour; 1,3-diazine. It is a weakly basic soluble heterocyclic compound and can be prepared from barbituric acid. Formula: C4H4N2
2. (Elements & Compounds) Also called: pyrimidine base any of a number of similar compounds having a basic structure that is derived from pyrimidine, including cytosine, thymine, and uracil, which are constituents of nucleic acids
[C20: variant of pyridine]

py•rim•i•dine

(paɪˈrɪm ɪˌdin, pɪ-)

n.
1. a heterocyclic compound, C4H4N2, that is the basis of several important biochemical substances.
2. one of several pyrimidine derivatives, esp. the bases cytosine, thymine, and uracil, which are fundamental constituents of nucleic acids.
[1880–85;b. pyridine and imide]

py·rim·i·dine

(pī-rĭm′ĭ-dēn′)
Any of a group of organic compounds having a single ring with alternating carbon and nitrogen atoms. Pyrimidines include the bases cytosine, thymine, and uracil, which are components of nucleic acids.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.pyrimidine - any of several basic compounds derived from pyrimidine
alkali, base - any of various water-soluble compounds capable of turning litmus blue and reacting with an acid to form a salt and water; "bases include oxides and hydroxides of metals and ammonia"
cytosine, C - a base found in DNA and RNA and derived from pyrimidine; pairs with guanine
T, thymine - a base found in DNA (but not in RNA) and derived from pyrimidine; pairs with adenine
2.pyrimidine - a heterocyclic organic compound with a penetrating odor
organic compound - any compound of carbon and another element or a radical
Translations
pyrimidine
References in periodicals archive ?
00 Compounds having the structure pyrimidine ring (hydrogenated or not hydrogenated) or piperazine ring except malonilsechovyny (barbituric acid) and its derivatives (narcotic, toxic, psychotropic substances and precursors)
NuCana, a clinical stage biopharmaceutical company, today presented exciting data for the anti-cancer agent NUC-3373, a novel pyrimidine NucleoTide Analogue (ProTide).
Pyranopyrimidine is a heterocyclic compound which is formed from a pyrano ring with pyrimidine .
Further studies, performed mainly at Stanford University, revealed that the phage T4 enzymes specifically and uniquely incise DNA containing photoproducts called pyrimidine dimers.
s case of pyrimidine 5'-nucleotidase deficiency and heterozygous [alpha]-thalassemia was an interesting co-existence (1).
You'll note that each base pair consists of a purine and a pyrimidine, such that the spacing between backbones is the same on an A:T base pair and a G:C base pair.
Methotrexate is well known as an inhibitor of dihydrofolate reductase MTX, but it also acts on a number of other enzymes, leading to interference with both purine and pyrimidine pathways and DNA methylation.
Thiophene, thiazole, pyrazole, isoxazole and pyrimidine derivatives isolated and fused being an integral part of DNA and RNA which play an essential role in several biological processes and have considerable chemical and pharmacological importance, particularly, the pyrimidine ring can be found in nucleoside antibiotics, antibacterials, cardio: vascular as well as agro chemical and vetcer products [1] In addition, many of these derivatives were found to possess a variety of pronounced activities such as an anti-inflammatory [2-6], antimalarial [7-9], anti-allergic [10-11], antimicrobial [12-17].
Tanaka has developed a polyethylene furandicarboxylate with a high crystallization rate and excellent heat resistance using an effective new thiol nucleating agent, pyrimidine thiol.
1) belongs to the amidohydrolase protein superfamily and catalyses the deamination of cytosine to uracil and ammonia in the pyrimidine salvage pathway.
Inhibition of pyrimidine biosynthesis (via suppression of DHODH) and interference with tyrosine kinase activity both appear to be involved.