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pyrimidine

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py·rim·i·dine  (p-rm-dn, p-)
n.
1. A single-ringed, crystalline organic base, C4H4N2, that forms uracil, cytosine, or thymine and is the parent compound of many drugs, including the barbiturates.
2. Any of several organic compounds derived from or structurally related to pyrimidine, especially the nitrogen bases uracil, cytosine, and thymine.

[Alteration of pyridine.]

pyrimidine [paɪˈrɪmɪˌdiːn]
n
1. (Chemistry / Elements & Compounds) a liquid or crystalline organic compound with a penetrating odour; 1,3-diazine. It is a weakly basic soluble heterocyclic compound and can be prepared from barbituric acid. Formula: C4H4N2
2. (Chemistry / Elements & Compounds) Also called pyrimidine base any of a number of similar compounds having a basic structure that is derived from pyrimidine, including cytosine, thymine, and uracil, which are constituents of nucleic acids
[variant of pyridine]

pyrimidine  (p-rm-dn)
Any of a group of organic compounds having a single six-member ring in which the first and third atoms are nitrogen and the rest are carbon. Pyrimidines include the bases cytosine, thymine, and uracil, which are components of DNA and RNA. Pyrimidine rings are also components of several larger compounds, such as thiamine and some synthetic barbiturates.
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.pyrimidine - any of several basic compounds derived from pyrimidine
alkali, base - any of various water-soluble compounds capable of turning litmus blue and reacting with an acid to form a salt and water; "bases include oxides and hydroxides of metals and ammonia"
cytosine, C - a base found in DNA and RNA and derived from pyrimidine; pairs with guanine
T, thymine - a base found in DNA (but not in RNA) and derived from pyrimidine; pairs with adenine
2.pyrimidine - a heterocyclic organic compound with a penetrating odor
organic compound - any compound of carbon and another element or a radical


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Pemetrexed is an antifolate/antimetabolite with several molecular targets involved in both pyrimidine and purine neosynthesis: thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT).
TS-1/S-1 is an oral pyrimidine fluoride-derived anticancer agent which has been available in Japan since 1999.
The vitamin appears to correct problems in pyrimidine metabolism, a compound important for the development of the spinal cord.
 
 
 
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