The unlicensed substances to which the vet pleaded guilty to having in his possession were catasol, a painkiller used in animals; quinidine
sulfate, used to treat atrial fibrillation in horses; and Hemo 15, a supplement that contains cobalt, a naturally occurring trace mineral for which there are established thresholds.
Small studies have shown the benefit of quinidine
, but overall, drug therapy is not proven to be beneficial.
is currently being used in patients with ICD and multiple shocks; cases in which ICD implantation is contraindicated; or for the treatment of supraventricular arrhythmias.
is an avid inhibitor of CYP2D6, even at very low dosages.
Cummings, told me that he cautions physicians against prescribing the dextromethorphan plus quinidine
combination to patients with Alzheimer's disease agitation, even though controlling Alzheimer's agitation is a major unmet need for patients and their families.
WASHINGTON--Daily treatment with a combined formulation of dextromethorphan and quinidine
led to a significant and clinically meaningful cut in agitation episodes among patients with Alzheimer's disease in a controlled, phase II 10-week study with 159 patients.
WASHINGTON -- Daily treatment with a combined formulation of dextromethorphan and quinidine
led to a significant and clinically meaningful cut in agitation episodes among patients with Alzheimer's disease in a controlled, phase II, 10-week study with 159 patients.
Some studies have evaluated the role of quinidine
in the treatment of Brugada syndrome and found it to be effective in preventing polymorphic VT and VF in this condition (10).
Goldstein and his colleagues tested the supplement against quinidine
, a known CYP2D6 inhibitor.
Parenteral artesunate, a first-line treatment for severe malaria in several countries, is associated with increased survival and has a better safety profile compared with parenteral quinine or quinidine
AVP-786 is a novel investigational drug product consisting of a combination of deuterium modified dextromethorphan and ultra-low dose quinidine
, said the company.
Cardiac toxicity has been a major concern with the use of IV quinine or quinidine
, with quinidine
considered to be more toxic than 4 , 6 quinine .