The same result was observed for quinolines
, an antifolate, or atovaquone (Table 1).
Efficacy of orally administered 2-substituted quinolines
in experimental murine cutaneous and visceral leishmaniases.
The nitrogen in the feedstock has three characteristics: 1) the N content of nitriles is high, 2) the content of basic nitrogen (anilines, pyridines, quinolines
and acridines) is about 29 wt%, and 3) the nonbasic nitrogen content is lower than that in general shale oils.
Topics covered include ring synthesis, substituent installation and modification, reduction to partially hydrogenated pyridines, piperidines, and quinolines
, alkaloid synthesis, fluorination, and the use of pyridines as reagents.
On the other hand quinolines
exhibit antimalarial , antiplasmodial , antiproliferative , antibacterial , antifungal .
Though halogenated quinolines
have been used for a long time, information on their metabolism is scarce.
In a potential breakthrough, Oregon researchers have developed new drugs that not only kill malaria parasites, but also restore the effectiveness of a generation of inexpensive drugs call quinolines
, to which parasites have become resistant.
In vitro activity of quinolines
against Plasmodium falciparum in Gabon.
In vivo efficacy of oral and intra-lesional administration of 2-substituted quinolines
in experimental treatment of new world cutaneous Leishmaniasis caused by Leishmania amazonensis.
and dithiocarbamates find use in specialized applications.
According to a report of the work in the November-December JOURNAL OF FOOD SCIENCE, all fibers bound at least 8 percent of the quinolines
, and some bound as much as 22 percent, depending on the fiber and the particular quinoline
Again, some polycyclic aromatic nitrogen hydrocarbons (PANH) present in the aromatic fraction of shale oil, such as quinolines
and methylquinolines, are extremely harmful to human health due to their toxicity, mutagenicity and carcinogenicity [15, 16].