quinolone

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Related to Quinolones: ciprofloxacin, Aminoglycosides

quin·o·lone

 (kwĭn′ə-lōn′)
n.
Any of a class of synthetic broad-spectrum antibacterial drugs derived from quinoline compounds.

quinolone

(ˈkwɪnəˌləʊn)
n
1. (Pharmacology) any of a group of synthetic antibiotics, including ciprofloxacin, that inactivate an enzyme required for the replication of certain microorganisms
2. (Pathology) any of a group of synthetic antibiotics, including ciprofloxacin, that inactivate an enzyme required for the replication of certain microorganisms
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This should include annual equipment performance maintenance, technical support in the case of loss of equipment performance or equipment breakdown along with associated training and technical support to set up system for a range of residue screening testing in fish tissue including providing array start up kits quinolones, tetracyclines in fish muscle this equipment will primarily be used to carry out screening of veterinary residues under the national residues control plan for aquaculture in the marine environment & food safety (mefs) service area
Roman Manetsch, PhD, USF associate professor of chemistry, and Dennis Kyle, PhD, USF professor of global health, were co-leaders of the USF team, which helped to discover and develop a series of potent compounds to combat malaria known as the 4-(1H)-quinolone-3-diarylethers, or quinolones.
The findings "reinforce what our gut instincts have been saying about prescribing for cystitis: Physicians are having more concerns about resistance and are therefore going to the second-line agents like quinolones, cephalosporins, and other medications," Jessina C.
Estimates from the late 1990s suggested that quinolones were the most prescribed antibacterial agent worldwide (1).
Before the emergence of bacterial plasmid-mediated quinolone resistance (PMQR) genes, research on the resistance mechanisms of (fluoro)quinolones were confined to mutations of chromosomal genes coding DNA gyrase or topoisomerase IV in the quinolone resistance determining region (QRDR) (Hopkins et al.
Quinolones have a bactericidal effect when these bind with two target enzymes, DNA gyrase and topoisomerase IV, which are essential for DNA replication within the cell.
Coli despite no local availability of broad-spectrum antibiotics known as quinolones.
Other quinolones may offer advantages over ciprofloxacin.
In addition to supporting platform technologies, the TB Alliance is developing nitroimidazopyrans, quinolones, macrolides and other classes of antibiotics.
To the Editor: Because of the significant interaction between quinolone antimicrobial agents and several divalent or trivalent cations, (1-4) we recently changed our computer-generated nurses' medication administration report (MAR) to schedule quinolones automatically 2 hours before products with these cations.
For that reason, their use in serious infections has been in large part supplanted by quinolones (such as ciprofloxacin) in adults and third-generation cephalosporins in children.
But over the last decade the rates of Campylobacter resistance to quinolones have gone from one or two percent to 21 percent.