Targeting homologous recombination using imatinib results in enhanced tumor cell chemosensitivity and radiosensitivity
Institute, is the first approach that has been clinically validated to guide radiation dosage based upon the Radiosensitivity
Index (RSI) of patients, company executives said.
Also, some studies found that soy isoflavones enhance radiosensitivity
, induce G2/M cell cycle arrest, inhibit the DNA repair mechanism, boost BAX gene expression, and inhibit BCL-2 and survivin gene expression (Free Radic Biol Med.
Conclusion: The evaluation of cells viability showed that TMZ in combination with IR on glioma cells led to a significant radiosensitivity
compared to IR alone.
While there is an absolute need for greater precision in prescribing radiotherapy in patients with breast cancer, Speers and his colleagues formulated a molecular signature of radiation response from in vitro studies, and they found that there was no relationship between radiosensitivity
and molecular subtype (34).
Because of the exquisite radiosensitivity
of lymphocytes, a variety of protocols for extranodal lymphoma have been used effectively.
Inhibiting GLUT-1 expression and PI3K/Akt signaling using apigenin improves the radiosensitivity
of laryngeal carcinoma in vivo.
Some authors support radiotherapy treatment in all cases, justifying the high radiosensitivity
of these tumours and the high rate of local recurrence.
It is important to recognize lymphoma as distinct from squamous cell carcinoma because of different clinical course and marked radiosensitivity
of lymphoma relative to squamous cell carcinoma.
Pink bollworm: 1 Effects of male irradiation and ejaculate sequence' on female ovipositional response and sperm radiosensitivity
Inhibition of STAT3 and ErbB2 suppresses tumor growth, enhances radiosensitivity
, and induces mitochondria-dependent apoptosis in glioma cells.
9) It is speculated that defects in DNA repair mechanisms seen in these patients may increase radiosensitivity
and susceptibility to carcinogenesis in the surviving cells.