In all domains of life, Dna replication relies on dedicated initiator proteins that recognize and bind specific genomic sites, Termed replication origins, To facilitate the loading of ring-shaped replicative
helicases onto dna.
Fundamental (gain-of-function) research on transmissibility, host-range restriction, drug resistance, immunogenicity, pathogenicity, and replicative
ability would also benefit global public health.
This situation is unlikely replicative
itself, as there are no other countries in that income band with such high levels of spending at cafes.
We also confirmed that the plaque sizes of the PRVABC59 (American clade) and MR766-NIID (African lineage) strains resemble that of ZIKV/Hu/Chiba/ S36/2016 (data not shown), suggesting that the Southeast Asian clade Zika virus strains might have a lower cytotoxicity and replicative
ability than the American clade and African lineage.
The proliferative index (Mib-1) in the tumorous area was 5% in contrast to total absence in the non-neoplastic mucosa, thus suggesting a replicative
DNA damage signaling mediates the functional antagonism between replicative
senescence and terminal muscle differentiation," Genes & Development, 2017; 31 (7): 648 DOI: 10.
Senescence in an organism's life is a phase of developmental decline, and a loss of replicative
capacity in cell culture.
The two studies, SC1401 and SC1402, were designed to be replicative
Phase 3 randomised, multicentre, double-blind, placebo-controlled studies that aimed to evaluate the efficacy and safety of sarecycline.
BASED RESEARCHERS have isolated replicative
Zika virus RNA from the brain tissue of infants with microcephaly, and the placenta and fetal tissues from women suspected of being infected with Zika virus during pregnancy.
There are two types of entrepreneurship and these are the replicative
type and the Schumpeterian typed named after Joseph Alois Schumpeter, an Austrian born American economist, who taught at Harvard University from 1932 until his death at 66 years old in 1950.
Studies like these led to the development of conditionally replicative
adenoviruses (CRAds), which are unable to replicate in normal host cells but selectively target tumour cells19.
Although spread is primarily by Aedes species mosquitoes, two instances of sexual transmission of Zika virus have been reported (1,2), and replicative
virus has been isolated from semen of one man with hematospermia (3).