back mutation

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back mutation

n.
A reversal process whereby a gene or other nucleotide sequence that has undergone mutation returns to its previous state.

back mutation

n
(Genetics) genetics the reversion of a mutant to the original phenotype
References in periodicals archive ?
The Ames reverse mutation assay (OECD 471) uses genetically modified bacteria that can only grow in growth limiting media conditions if a mutation occurs that allows the bacteria to again synthesize key nutrients.
The basic requirement is to assess genotoxicity initially in a bacterial reverse mutation test, followed by tests in mammalian cells in vitro and a mandatory test in a mammalian model in vivo.
Tests performed were acute oral toxicity, repeated dose 28-day oral toxicity, bacterial reverse mutation, in vitro chromosome aberration, micronucleus and dermal sensitization, as well as a 4-week immunotoxicity study.