reverse transcriptase


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Related to reverse transcriptase: reverse transcription, Reverse transcriptase inhibitors

reverse transcriptase

n.
A polymerase that catalyzes the formation of DNA on an RNA template, found in the retroviruses and in certain other viruses, such as hepatitis B virus.

reverse transcriptase

(trænˈskrɪpteɪz)
n
(Biochemistry) an enzyme present in retroviruses that copies RNA into DNA, thus reversing the usual flow of genetic information in which DNA is copied into RNA

reverse′ tran•scrip′tase

(trænˈskrɪp teɪs, -teɪz)
n.
a retrovirus enzyme that synthesizes DNA from viral RNA, the reverse of the usual DNA-to-RNA replication: used in genetic engineering.
[1970–75]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.reverse transcriptase - a polymerase that catalyzes the formation of DNA using RNA as a template; found especially in retroviruses
polymerase - an enzyme that catalyzes the formation of new DNA and RNA from an existing strand of DNA or RNA
References in periodicals archive ?
The SVM technique was adequate to produce an effective QSAR model and outperformed those in the literature and the predictive stages for the inhibitory activity of reverse transcriptase by HEPT derivatives.
The researchers found telomerase reverse transcriptase gene mutations in three of the 292 smokers with emphysema, a disease in which the air sacs in the lungs are gradually damaged, making the person increasingly more short of breath.
20 November 2014 - US recombinant enzymes and related reagents maker New England Biolabs, or NEB, said yesterday it had introduced WarmStart RTx Reverse Transcriptase, a next generation, thermostable reverse transcriptase, especially designed for nucleic acid detection.
Separately, the company signed an agreement with Yamasa Corporation based in Choshi, Japan, to develop EFdA (4'-ethynyl-2-fluoro-2'-deoxyadenosine), a novel nucleoside reverse transcriptase inhibitor candidate that is in preclinical studies and has shown antiviral activity toward highly resistant HIV strains.
We compared the telomere length and telomerase activity in DPaSCs with those in MSCs and found that DPaSCs possessed ideal characteristics on telomere length, telomerase activity and reverse transcriptase activity, making DPaSCs suitable alternative candidates for regenerative medicine.
About 10 years ago, biochemical studies in several laboratories established that AZT-resistant HIV-1 reverse transcriptase uses adenosine triphosphate, or ATP, which moves energy around inside the cell, to remove the AZT.
Intrapartum and neonatal single-dose nevirapine are commonly used and essential in the prevention of mother-to-child transmission of HIV in resource-poor settings, but may induce resistance to other non-nucleoside reverse transcriptase inhibitors.
They recorded the incidence of myocardial infarction during the follow-up period and looked at the associations between myocardial infarction and exposure to protease inhibitors or non-nucleoside reverse transcriptase inhibitors.
Viral enzymes reverse transcriptase, protease, and integrase are transcribed from which of the following genes?
Reverset is a nucleoside analog reverse transcriptase inhibitor that is being developed as a once-daily oral HIV therapy by Incyte Corporation and Pharmasset, Inc.
Even though other studies showed that elevations in triglyceride and cholesterol and body shape changes were also seen with the other classes of drugs and not just the protease inhibitors, the field had moved to using a non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimen as part of first-line therapy.
Roche announced in April that it would stop malting its nucleoside reverse transcriptase inhibitor Hivid (ddC) and its protease inhibitor Fortovase in 2006.

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