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cofactor |
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cofactor [ˈkəʊˌfæktə] n 1. (Mathematics) Maths a number associated with an element in a square matrix, equal to the determinant of the matrix formed by removing the row and column in which the element appears from the given determinant See minor 2. (Life Sciences & Allied Applications / Biochemistry) Biochem a nonprotein substance that forms a complex with certain enzymes and is essential for their activity. It may be a metal ion or a coenzyme
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11) Test for von Willebrand disease For more than two decades, the ristocetin cofactor (RCo) assay, which measures the vWF-mediated agglutination of platelets in the presence of the antibiotic ristocetin, has been the most common method for measuring the functional activity of vWF. The company also developed the first automated ristocetin cofactor activity test that detects Von Willebrand disease, which is the most common inherited bleeding disorder. These variants are differentiated on the basis of a panel of lab tests that include the bleeding time, platelet count, partial thromboplastin time, yon Willebrand factor (vWF) activity and antigen, factor VIII levels, ristocetin cofactor, and vWF multimeric composition. |
ristocetin cofactor |
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