The ongoing Phase II/III in PPMS will test the effect of rituximab
versus placebo in 450 patients for a total of 2 years of therapy (four courses).
Trial results have shown that maintenance treatment with rituximab
can almost halve the risk of death for patients with follicular non-Hodgkin lymphoma (NHL).
The anticancer drug rituximab
thwarts inflammatory nerve damage in the brain and curbs relapses in people with multiple sclerosis (MS), a study suggests.
After years of case reports and small series, three publications this year now provide us with timely data demonstrating the safety and efficacy of an anti-CD20 monoclonal antibody, rituximab
, in patients with HIV-associated MCD.
Emmanuelle Waubant is one of a team of investigators at the University of California San Francisco MS Center collaborating in multicenter trials of rituximab
After completion of the rituximab
therapy, the factor XIII activity was 58% with no inhibitor present.
is a monoclonal antibody against CD20 antigen expressed on B-lymphocytes.
VIENNA -- B-cell depletion with rituximab
led to significant improvements in patients with CNS neuropsychiatric disability associated with systemic lupus erythematosus, according to a preliminary report presented by C.
Infusion-related toxicities were typically grade 1 or 2 and were associated with pre-administration of Rituximab
More recently, the AMC trial 010 was unable to show that HIV-positive people benefited from the addition of Rituximab
(a monoclonal antibody that attacks cancerous lymphoma cells) to a standard chemotherapy regimen.
In trials, the drug, rituximab
, was so effective on some patients they were able to return to work and even go to the gym for the first time after 20 years.
The drug, rituximab
, acts by suppressing antibody production within the immune system and breaking a key part of the cycle that leads to arthritic inflammation.