In addition to these, there are a number of 1,2,4-triazole-containing drugs on the market like letrozole, vorozole and anastrozole (antitumor) , ribavirin, viramidine (antiviral) , rizatriptan
(antimigrane) , fluconazole, itraconazole, terconazole (antifungal) , loreclezole (sedative and anticonvulsant) , hexaconazole, myclobutanil, triadimefon and tebuconazole (fungicide) .
Rizaport is a proprietary oral thin film formulation of rizatriptan
benzoate that rapidly dissolves and releases its active ingredient in the mouth, resulting in efficient absorption of the drug.
v) YELIVA (ABC294640) - a Phase II-stage, orally- administered, first-in-class SK2 selective inhibitor targeting multiple oncology, inflammatory and gastrointestinal indications; (vi) MESUPRON - a Phase II- stage first-in-class, orally-administered uPA inhibitor, targeting gastrointestinal and other solid tumors and (vii) RIZAPORT (RHB-103) - an oral thin film formulation of rizatriptan
for acute migraines, with a U.
Mefenamic acid, sumatriptan, and rizatriptan
have category B recommendations for abortive treatment for menstrual migraines (table 2 (11-16)).
Two randomized case-controlled trials evaluating the therapeutic effects of triptan during the acute phase of VM have been published [37, 38]: one showed that 38% of VM patients improved when treated with zolmitriptan (5 mg), whereas only 22% of patients in the placebo group improved  and the other reported that motion sickness caused by vestibular stimulation in patients with migraine was significantly reduced following treatment with rizatriptan
compared with a placebo .
versus sumatriptan in the acute treatment of migraine.
Recent product introductions from Camber include aripiprazoe (Abilify), lamivudine/zidovudine (Combivir), montelukast (Singulair), pantoprazole (Protonix); raloxifene (Evista), rizatriptan
(Maxalt); sildenafil (Revatio), valsartan (Diovan) and zolmitriptan (Zomig).
This class of medications includes naratriptan, rizatriptan
, eletriptan, sumatriptan, zolmitriptan, almotriptan, and frovatriptan.
, eletriptan, and almotriptan), which are used for more severe migraines, promote vasoconstriction and block pain pathways by activating certain serotonin receptors in cranial blood vessels (Bajwa 2012).
Triptans like Sumatriptan and Zolmitriptan are also available as nasal sprays whereas rizatriptan
and zolmitriptan are available as tablets that dissolve in the mouth.
Exposure to rizatriptan
during pregnancy: Post-marketing experience up to 30 June 2004.
To test the hypothesis that placebo and medication treatment-related outcomes would improve progressively as the information provided to subjects varied from negative (indicating 0% chance of receiving active medication) to uncertain (indicating a 50% chance of receiving active medication) to positive (indicating 100% chance of receiving active medication), the investigators randomly assigned 66 adult subjects aged 18 years and older who had experienced episodic migraine in the past 3 years to receive placebo or active treatment with 10 mg of rizatriptan
(Maxalt-MLT) during six migraine attacks.