rofecoxib


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Related to rofecoxib: Etoricoxib
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Noun1.rofecoxib - a Cox-2 inhibitor (trade name Vioxx) that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004
Cox-2 inhibitor - an anti-inflammatory drug that fights pain and blocks Cox-2 activity without impeding the activity of Cox-1; increases the risk of heart attacks; "Cox-2 inhibitors reduce the symptoms of arthritis without endangering the stomach and kidneys"
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Rofecoxib is a non-narcotic analgesic, has no effect on bleeding time relative to placebo and is the only COX-2 selective NSAID ever approved in the US to demonstrate a reduced risk of gastrointestinal bleeding versus a traditional NSAID in a controlled trial.
Researchers from Germany, Finland and Canada studied ordinary painkillers or oral non-steroidal anti-inflammatory drugs (NSAIDs) like naproxen, celebrex, ibuprofen, voltaren and rofecoxib.
The study claims using NSAIDs at a high dose for eight to 30 days was "particularly harmful" when people took more than 1200mg a day of ibuprofen, 750mg a day of naproxen and more than 25mg a day of rofecoxib.
The highest risk was found to be in the first month of taking the pills and to those on a high daily dose - such as more than 1,200mg of ibuprofen, 750mg of naproxen and 25mg rofecoxib.
For seven traditional NSAIDs (diclofenac, ibuprofen, indomethacin, ketorolac, naproxen, nimesulide, and piroxicam) and the COX-2 inhibitors etoricoxib and rofecoxib, the odds ratios for heart failure with current use ranged from 1.
57), and etoricoxib 60 mg and rofecoxib 25 mg were comparably effective.
Patients were randomised in three groups before surgery--namely a rofecoxib group, ibuprofen group, and a placebo group--and were given their allocated analgesia and paracetamol one hour pre-operatively.
These include rofecoxib (Vioxx), valdecoxib (Bextra), and sibutramine (Meridia).
Rofecoxib (Merck) was introduced in 1999 as an effective, safer alternative to non-steroidal anti-inflammatory drugs for treating pain associated with osteo-arthritis.
A significant increase in risk was seen after 1 week of treatment with, ibuprofen, in the first week of treatment with rofecoxib (which has been withdrawn from the market), and after 14-30 days with celecoxib.
A new multi-year analysis of 31 trials and more than 116,000 patients taking naproxen (Aleve), ibuprofen (Advil), diclofenac (Votaren), celecoxib (Celebrex), etoricoxib (Arcoxia), lumiracoxib (Prexige) and rofecoxib (Vioxx) was published online Jan.