Peripheral blood smears were routinely prepared from all TTP patients and frequency of the schistocyte
on the blood film was estimated as mild, moderate and severe at 1000X magnification.
9]), increased lactate dehydrogenase activity (517 IU/L) and schistocyte
count was 3%.
Evidence for microangiopathic haemolysis should be sought by monitoring platelet count, haemoglobin, lactate dehydrogenase and schistocyte
measurements on the peripheral smear.
Red cell morpho- logy was normochromic normocytic with microsphe- rocytes and an occasional schistocyte
An occasional ([less than]1%) schistocyte
or helmet cell also may be seen.
The patient had fever, transient neurologic symptoms, progressive deterioration in renal function, thrombocytopenia, and a previous episode of TTP that had responded to plasma exchange; however, she had normal serum haptoglobin levels and only an occasional schistocyte
on the peripheral blood smear.
Serum markers of TA-TMA include elevated lactate dehydrogenase, de novo thrombocytopenia not explained by other post-HSCT complications, Coombs test-negative hemolytic anemia (often hallmarked by increased free plasma hemoglobin and decreased haptoglobin), peripheral schistocytes
, and signs of renal dysfunction (proteinuria and elevated creatinine).
Hematological markers demonstrated HCT-TMA with thrombocytopenia, elevated lactate dehydrogenase, and schistocytes
Neutrophil Changes Erythrocyte Changes Cytoplasmic vacuoles Crenated (burr cells, echinocytes) Loss of granulations Spherocytes Elongated nuclei Elongated (elliptocytes) (loss of segmentation) Undefined chromatin Schistocytes
(fragments) (appear liquefied) Pyknotic nuclei (necrobiotic) Hypochromic Cytoplasm rupture Smudge (basket) cells
1g/dl) and thrombocytopenia (plt=84*10^9/L) with 7% schistocytes
on peripheral smear.
Peripheral blood films in these cases revealed hypochromia and microcytosis, target cells and schistocytes
and pencil cells in those with iron deficiency complicating beta thalassemia trait.
9, blood picture showed schistocytes
= 2 + RBG = 18 mmol/L, reticulocytes = 1.