self-tolerance


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self-tol·er·ance

(sĕlf′tŏl′ər-əns)
n.
Tolerance by the body's immune system to its own cells and tissues.
References in periodicals archive ?
Immune checkpoints are inhibitory receptors and their ligands, which are crucial for the maintenance of self-tolerance (that is, the prevention of autoimmunity) and for the protection of tissues from damage when the immune system is responding to pathogenic infection or other injuries.
In humans, this novel approach is utilized to help the body's immune system recognize cancerous cells created in the body as 'foreign', overcoming the body's self-tolerance of these cells and mounting an immune response to clear them.
The outcome is to try and reinstate self-tolerance, where an individual's immune system ignores its own tissues while remaining fully armed to protect against infection.